2024-03-29T01:02:21Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003759
2022-12-14T04:39:40Z
461:462
Validity of reduced radiation dose for localized diffuse large B-cell lymphoma showing a good response to chemotherapy
Koiwai, Keiichiro
Sasaki, Shigeru
Yoshizawa, Eriko
Ina, Hironobu
Fukazawa, Ayumu
Sakai, Katsuya
Ozawa, Takesumi
Matsushita, Hirohide
Kadoya, Masumi
diffuse large B-cell lymphoma
radiation dose
radiotherapy
chemotherapy
To evaluate the validity of a decrease in the radiation dose for patients who were good responders to chemotherapy for localized diffuse large B-cell lymphoma (DLBCL), 91 patients with localized DLBCL who underwent radiotherapy after multi-agent chemotherapy from 1988-2008 were reviewed. Exclusion criteria were as follows: central nervous system or nasal cavity primary site, or Stage II with bulky tumor (>= 10 cm). Of these patients, 62 were identified as good responders to chemotherapy. They were divided into two groups receiving either a higher or a lower radiation dose (32-50.4 Gy or 15-30.6 Gy, respectively). There were no statistically significant differences between the lower and higher dose groups in progression-free survival, locoregional progression-free survival or overall survival. Adaptation of decreased radiation dose may be valid for localized DLBCL patients who show a good response to chemotherapy.
Article
JOURNAL OF RADIATION RESEARCH. 55(2):359-363 (2014)
journal article
OXFORD UNIV PRESS
2014-03
application/pdf
JOURNAL OF RADIATION RESEARCH
2
55
359
363
0449-3060
AA00705792
https://soar-ir.repo.nii.ac.jp/record/3759/files/Validity_reduced_radiation_dose_localized_diffuse.pdf
eng
24187329
https://pubmed.ncbi.nlm.nih.gov/24187329
10.1093/jrr/rrt122
https://doi.org/10.1093/jrr/rrt122
Copyright© The Author 2013. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Therapeutic Radiology and Oncology. / This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.