2024-03-29T06:47:28Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003799
2022-12-14T04:12:02Z
461:462
Metastatic Carcinoma to Subcutaneous Tissue and Skeletal Muscle: Clinicopathological Features in 11 Cases
Yoshimura, Yasuo
Isobe, Ken-ichi
Koike, Tsuyoshi
Arai, Hideki
Aoki, Kaoru
Kato, Hiroyuki
soft tissue
neoplasms
metastasis
immunohistochemistry
Objective: Metastatic carcinoma to subcutaneous tissue or skeletal muscle is relatively rare. The present study aimed to clarify the clinicopathological features for confirming the diagnosis as soft tissue metastasis and determining the primary site. Methods: We reviewed records of 11 patients with soft tissue metastasis who were in our institution from 1996 to 2009. Results: In 9 of 10 patients who underwent magnetic resonance imaging, findings consisted of poorly circumscribed high-intensity lesions around the tumor on T2-weighted images, irregular peritumoral enhancement and poorly enhanced lesions at the center of the tumor on T1-weighted images. Systematic immunohistochemical examination was more valuable for diagnosing as soft tissue metastasis and confirming the primary site. The expression patterns of cytokeratins 7 and 20 and tissue-specific antibodies such as thyroid transcription factor-1, MUC5AC and CDX2 were useful diagnostic markers. The primary site could be determined in five patients with cytokeratin 7/20 immunophenotype and positivity for tissue-specific antibodies. In four cases, determination of the primary site finally became possible by comparison with the histological findings of operative specimens in past carcinoma and/or in consideration of radiological findings and the results of cytokeratin 7/20 phenotyping. Conclusions: Systematic immunohistochemical examination is helpful for confirmation of the primary origin in soft tissue metastasis of carcinoma in addition to clinical information such as the history and condition of past carcinoma, radiological findings and comparison between the histology of biopsy specimens and past carcinoma.
Article
JAPANESE JOURNAL OF CLINICAL ONCOLOGY. 41(3):358-364 (2011)
journal article
OXFORD UNIV PRESS
2011-03
application/pdf
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
3
41
358
364
0368-2811
AA00690866
https://soar-ir.repo.nii.ac.jp/record/3799/files/Metastatic_Carcinoma_Subcutaneous_Tissue_Skeletal_Muscle.pdf
eng
21051532
https://pubmed.ncbi.nlm.nih.gov/21051532
10.1093/jjco/hyq199
https://doi.org/10.1093/jjco/hyq199
Copyright© 2010 The Authors. Published by Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Japanese Journal of Clinical Oncology following peer review. The definitive publisher-authenticated version Jpn. J. Clin. Oncol. (2011) 41 (3): 358-364 is available online at: doi: 10.1093/jjco/hyq199.