2024-03-28T23:14:19Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003810
2022-12-14T04:40:19Z
461:462
Iodine-123 metaiodobenzylguanidine scintigraphic assessment of pulmonary vascular status in patients with chronic obstructive pulmonary disease
Koizumi, Tomonobu
Urushihata, Kazuhisa
Hanaoka, Masayuki
Tsushima, Kenji
Fujimoto, Keisaku
Fujii, Tadashige
Kubo, Keishi
airflow limitation
metaiodobenzylguanidine
pulmonary artery pressure
pulmonary hypertension
Background and objective: Lung uptake of iodine-123 metaiodobenzylguanidine ((123)I-MIBG) is used as an indicator of pulmonary endothelial function. Decreased lung uptake of (123)I-MIBG has been demonstrated in patients with COPD as compared with normal subjects. The present study was performed to examine the relationship between lung uptake of (123)I-MIBG and pulmonary artery pressure (Ppa) at rest and during exercise, in patients with COPD. Methods: (123)I-MIBG scintigraphy was performed in 19 patients with COPD. Anterior planar images were acquired 15 min after the injection of (123)I-MIBG, and the total lung to upper mediastinum ratio (LMR) was calculated for both lungs. Right heart catheters were used to monitor Ppa continuously at rest and during exercise. Exercise was performed on an electrically braked bicycle ergometer at a constant workload of 25 W for 3 min. Results: In COPD patients the LMR were not correlated with the pulmonary function parameters measured before exercise, including FEV(1), PaO(2), DL(CO), or Ppa at rest. However, the percentage increase in Ppa during exercise was significantly correlated with LMR. Conclusions: Evaluation of the kinetics of lung uptake of (123)I-MIBG may be a novel scintigraphic tool for the assessment of exercise-induced pulmonary hypertension in patients with COPD.
Article
RESPIROLOGY. 15(8):1215-1219 (2010)
journal article
WILEY-BLACKWELL PUBLISHING, INC
2010-11
application/pdf
RESPIROLOGY
8
15
1215
1219
1323-7799
AA11097269
https://soar-ir.repo.nii.ac.jp/record/3810/files/Iodine-123_metaiodobenzylguanidine_123I-MIBG_scintigraphic_assessment.pdf
eng
20920125
https://pubmed.ncbi.nlm.nih.gov/20920125
10.1111/j.1440-1843.2010.01853.x
https://doi.org/10.1111/j.1440-1843.2010.01853.x
Copyright© 2010 The Authors; Respirology Copyrigh? 2010 Asian Pacific Society of Respirology