2024-03-29T02:23:31Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003910
2022-12-14T04:40:29Z
461:462
Vitamin D-3 induces expression of human cathelicidin antimicrobial peptide 18 in newborns
Misawa, Yuka
Baba, Atsushi
Ito, Susumu
Tanaka, Miyuki
Shiohara, Masaaki
Human
Neutrophils
Phagocytosis
This research was originally published in International Journal of Hematology. Authors. Misawa, Y; Baba, A; Ito, S; Tanaka, M; Shiohara, Title. Vitamin D-3 induces expression of human cathelicidin antimicrobial peptide 18 in newborns, IJH. Year 2009;Vol. 90, Issue. 5:pp561-pp570. Copyright (c) 2009 by The Japanese Society of Hematology.
Bactericidal activities of neutrophils occur by two distinctive mechanisms that are oxygen-dependent and -independent. Human cathelicidin antimicrobial peptide 18 (hCAP18), also known as LL-37/FALL-39, is a neutrophil-specific granule protein. We compared the content of hCAP18 and neutrophil gelatinase-associated lipocalin (NGAL), another neutrophil-specific granule protein, in neutrophils of both neonates and adults by flow cytometry. The percentage as well as fluorescence intensity ratio of hCAP18 and NGAL expression in neonate neutrophils were significantly lower than in adults. Expression of hCAP18 in monocytes, however, was not significantly different between neonates and adults. Both hCAP18 and NGAL expression increased in an age-dependent fashion. Plasma concentration of these peptides measured by enzyme-linked immunosorbent assay was not significantly different between neonates and adults. Oral intake of 1 alpha hydroxy vitamin D-3 (1 alpha(OH)D-3) in rickets patients for 4 weeks significantly increased hCAP18 expression in neutrophils compared to age-matched healthy controls without 1 alpha(OH)D-3, indicating the potential of vitamin D-3 as a regulator of the innate immune response of neonates.
Article
INTERNATIONAL JOURNAL OF HEMATOLOGY. 90(5):561-570 (2009)
journal article
SPRINGER TOKYO
2009-12
application/pdf
INTERNATIONAL JOURNAL OF HEMATOLOGY
5
90
561
570
0925-5710
AA10797094
https://soar-ir.repo.nii.ac.jp/record/3910/files/Vitamin_D-3_induces_expression.pdf
eng
19943126
https://pubmed.ncbi.nlm.nih.gov/19943126
10.1007/s12185-009-0452-9
https://doi.org/10.1007/s12185-009-0452-9