2024-03-28T18:40:10Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00004380
2023-02-24T00:46:44Z
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ガンマグロブリン大量療法とプレドニゾロン併用療法が奏功した妊娠合併急性型特発性血小板減少性紫斑病の1例
A Case of Acute Idiopathic Thrombocytopenic Purpura during Pregnancy Successfully Treated with High-Dose γ-Globulin and Prednisolone
牧島, 秀樹
北野, 喜良
石田, 文宏
清澤, 研道
望月, 太郎
林, 圭介
田中, 征雄
長田, 敦夫
acute idiopathic thrombocytopenic purpura
pregnancy
combination therapy of γ-globulin and prednisolone
急性型特発性血小板減少性紫斑病
妊娠
ガンマグロブリンとプレドニゾロン併用療法
We report a case of acute idiopathic thrombocytopenic purpura (ITP) during pregnancy, which was successfully treated by a combination of high-dose γ-globulin and prednisolone (PSL).A 30-year-old female was admitted to our hospital in the 11th week of pregnancy due to bleeding.Laboratory data revealed severe thrombocytopenia (2,000/μl)with normal red blood cell and white blood cell counts,and she was diagnosed as having ITP.Both PSL alone (45mg/day for 4 weeks)and high-doseγ-globulin therapy alone (400mg/kg/day for 5 days)were transiently effective but resulted in a rapid decrease in the platelet count to under 10,000/μl. However,a combination of PSL (45mg/day,for 2 weeks)and high-doseγ-globulin (400mg/kg/day for 5 days) markedly increased her platelet count,which was maintained at over 90,000/μl.She delivered a healthy 2,050g male vaginally without complications in the 39th week of pregnancy. Although PSL was discontinued after delivery, no thrombocytopenia was observed. A combination of PSL and high-dose γ-globulin may be effective for cases of refractory ITP during pregnancy.
Article
信州医学雑誌 47(4): 309-314(1999)
journal article
信州医学会
1999-08-10
application/pdf
信州医学雑誌
4
47
309
314
0037-3826
AN00120815
https://soar-ir.repo.nii.ac.jp/record/4380/files/Shinshu_Med47-4-05.pdf
jpn