2024-03-29T04:42:16Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00010238
2022-12-14T04:10:38Z
1016:1017
Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides from beta-Lactoglobulin Secreted by Lactococcus lactis
Shigemori, Suguru
Oshiro, Kazushi
Wang, Pengfei
Yamamoto, Yoshinari
Wang, Yeqin
Sato, Takashi
Uyeno, Yutaka
Shimosato, Takeshi
Previous studies showed that hydrolysates of beta-lactoglobulin (BLG) prepared using gastrointestinal proteases strongly inhibit dipeptidyl peptidase-IV (DPP-IV) activity in vitro. In this study, we developed a BLG-secreting Lactococcus lactis strain as a delivery vehicle and in situ expression system. Interestingly, trypsin-digested recombinant BLG from L. lactis inhibited DPP-IV activity, suggesting that BLG-secreting L. lactis may be useful in the treatment of type 2 diabetes mellitus.
Article
BIOMED RESEARCH INTERNATIONAL. 2014:393598 (2014)
journal article
HINDAWI PUBLISHING CORPORATION
2014-01
application/pdf
BIOMED RESEARCH INTERNATIONAL
2014
393598
2314-6133
https://soar-ir.repo.nii.ac.jp/record/10238/files/Generation_Dipeptidyl_Peptidase-IV-Inhibiting_Peptides.pdf
eng
10.1155/2014/393598
https://doi.org/10.1155/2014/393598
Copyright© 2014 Suguru Shigemori et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.