2024-03-28T09:47:04Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00010250
2022-12-14T03:59:34Z
1016:1017
Syntheses of procyanidin B2 and B3 gallate derivatives using equimolar condensation mediated by Yb(OTf)(3) and their antitumor activities
Suda, Manato
Katoh, Miyuki
Toda, Kazuya
Matsumoto, Kiriko
Kawaguchi, Koichiro
Kawahara, Sei-ichi
Hattori, Yasunao
Fujii, Hiroshi
Makabe, Hidefumi
Polyphenol
Condensation
Lewis acid
Procyanidin gallate
Antitumor
Synthesis of procyanidin B2 and B3 gallate derivatives, 3-O-gallate, 3 ''-O-gallate, and 3,3 ''-di-O-gallate, were synthesized using equimolar condensation mediated by Yb(OTf)(3). Synthesized compounds showed significant antitumor effects against human prostate PC-3 cell lines. Their activities were weaker than well-known EGCG and prodelphinidin B3.
Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 23(17):4935-4939 (2013)
journal article
PERGAMON-ELSEVIER SCIENCE LTD
2013-09-01
application/pdf
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
17
23
4935
4939
0960-894X
AA1079577X
https://soar-ir.repo.nii.ac.jp/record/10250/files/Syntheses_procyanidin_B2_B3_gallate_derivatives.pdf
eng
23867167
https://pubmed.ncbi.nlm.nih.gov/23867167/
10.1016/j.bmcl.2013.06.061
https://doi.org/10.1016/j.bmcl.2013.06.061
Copyright© 2013 Elsevier Ltd.