2024-03-29T09:28:41Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00010252
2022-12-14T04:11:20Z
1016:1017
Syntheses of prodelphinidin B3 and C2, and their antitumor activities through cell cycle arrest and caspase-3 activation
Fujii, Wataru
Toda, Kazuya
Kawaguchi, Koichiro
Kawahara, Sei-ichi
Katoh, Miyuki
Hattori, Yasunao
Fujii, Hiroshi
Makabe, Hidefumi
Polyphenols
Synthesis
Natural product
Anticancer agents
Total synthesis of prodelphinidin B3 and C2 have been accomplished. The key step is Lewis acid-mediated equimolar condensations between a catechin and/or gallocatechin nucleophile and a gallocatechin electrophile. The antitumor effects of synthetic prodelphidin B3 and C2 against PC-3 prostate cancer cell lines have been investigated. Both compounds showed significant antitumor effects. Their activity was almost the same as that of EGCG, a known antitumor agent.
Article
TETRAHEDRON. 69(17):3543-3550 (2013)
journal article
PERGAMON-ELSEVIER SCIENCE LTD
2013-04-29
application/pdf
TETRAHEDRON
17
69
3543
3550
0040-4020
AA00861787
https://soar-ir.repo.nii.ac.jp/record/10252/files/Syntheses_prodelphinidin_B3_C2_their_antitumor.pdf
eng
10.1016/j.tet.2013.02.087
https://doi.org/10.1016/j.tet.2013.02.087
Copyright© 2013 Elsevier Ltd.