2024-03-29T12:31:38Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00010290
2022-12-14T04:13:25Z
1016:1017
CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9
Shimosato, Takeshi
Fujimoto, Megumi
Tohno, Masanori
Sato, Takashi
Tateo, Mariko
Otani, Hajime
Kitazawa, Haruki
IL-33
CpG-ODN
TLR9
IL-1 superfamily
Streptococcus thermophilus
We previously reported the strong immunostimulatory effects of a CpG oligodeoxynucleotide (ODN), designated MsST, from the lacZ gene of Streptococcus (S.) thermophilus ATCC19258. Here we show that 24 h of stimulation with MsST in mouse splenocytes and peritoneal macrophages strongly induces expression of interleukin (IL)-33, a cytokine in the IL-1 superfamily. Other IL-1 superfamily members, including IL-1 alpha, IL-1 beta and IL-18, are down-regulated after 24 h of stimulation of MsST. We also found that MsST-induced IL-33 mRNA expression is inhibited by the suppressive ODN A151, which can inhibit Toll-like receptor 9 (TLR9)-mediated responses. This is the first report to show that IL-33 can be induced by CpG ODNs. The strong induction of IL-33 by MsST suggests that it may be a potential therapeutic ODN for the treatment of inflammatory disease. The presence of a strong CpG ODN in S. thermophilus also suggests that the bacterium may be a good candidate as a starter culture for the development of new physiologically functional foods.
Article
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 394(1):81-86 (2010)
journal article
ACADEMIC PRESS INC ELSEVIER SCIENCE
2010-03-26
application/pdf
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
1
394
81
86
0006-291X
AA00564395
https://soar-ir.repo.nii.ac.jp/record/10290/files/CpG_oligodeoxynucleotides_induce_strong_up-regulation.pdf
eng
20178773
https://pubmed.ncbi.nlm.nih.gov/20178773/
10.1016/j.bbrc.2010.02.110
https://doi.org/10.1016/j.bbrc.2010.02.110