2024-03-28T11:21:50Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00010317
2022-12-14T04:30:22Z
1016:1017
Anti-allergic effects of Lactobacillus crispatus KT-11 strain on ovalbumin-sensitized BALB/c mice
Tobita, Keisuke
Yanaka, Hiroyuki
Otani, Hajime
anti-allergic effect
antigen-presenting cells
Lactobacillus crispatus KT-11
mast cells
Th1
Th2 balance
The definitive version is available at www.blackwell-synergy.com
In this study, we investigated the effects of oral ingestion of Lactobacillus crispatus KT-11 strain (KT-11) on the immune response in an allergic rhinitis mouse model, ovalbumin (OVA)-sensitized BALB/c mice. Sneezing activity in mice that were administered a KT-11-supplemented diet was significantly lower than that in mice administered a KT-11-free diet (control diet) at age 11 weeks. We found that serum OVA-specific immunoglobulin E (IgE) levels and total number of interleukin (IL)-4+CD4+ spleen cells in mice that were administered a KT-11-supplemented diet were significantly lower than in mice administered a control diet. The ratio of spleen interferon-gamma+CD4+/IL-4+CD4+ cells was higher in the mice administered the KT-11-supplemented diet compared to that in mice administered the control or L. rhamnosus GG-supplemented diet. In contrast, the number of CD11b+CD80+ and Fc epsilon RI alpha+CD117+ cells was significantly lower in mice administered the KT-11-supplemented diet. These results suggested that KT-11 reduced OVA-induced allergic symptoms in BALB/c mice via the adjustment of the T helper type 1/T helper type 2 balance, and a decrease in the number of antigen-presenting cells and high affinity IgE receptor-positive mast cells.
Article
ANIMAL SCIENCE JOURNAL. 81(6):699-705 (2010)
journal article
Blackwell Publishing
2010-12
application/pdf
ANIMAL SCIENCE JOURNAL
6
81
699
705
1344-3941
AA11677214
https://soar-ir.repo.nii.ac.jp/record/10317/files/Anti-allergic_effects_Lactobacillus_crispatus.pdf
eng
21108691
https://pubmed.ncbi.nlm.nih.gov/21108691/
10.1111/j.1740-0929.2010.00795.x
https://doi.org/10.1111/j.1740-0929.2010.00795.x