2024-03-29T10:26:24Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00010605
2023-01-06T02:08:49Z
1016:1018:1019:1040
N置換グルコサミン誘導体の合成とそれらのアンジオテンシン I 変換酵素阻害能
Synthesis of N-Substituted Glucosamine Derivatives and Their Angiotensin I Converting Enzyme Inhibitory Activity
Kawakami, A
Kayahara, H
Ajiro, H
Tadasa, K
glucosamine
Angiotensin I converting enzyme
inhibitor
Inhibitory activity of glucosamine derivatives against angiotensin I converting enzyme (ACE) was investigated. Many N-substituted glucosamine derivatives were synthesized via 1,3,4,6-tetra-O-acetyl-glucosamine hydrochloride. Among them, N-(phenylalanyl-alanyl-prolyl)-glucosamine was found to be the most effective for ACE inhibition, and the half inhibitory concentrations (IC50_) was estimated as 300μM. Furthermore, N-(3,7-dimethyl-2(E/Z), 6-hexadien-carbonyl)-glucosamine and N-(p-dimethylamino benzoyl)-glucosamine were found to be effective for the inhibition of ACE, and their IC50 values were estimated as 5 mM and 8 mM, respectively.
Article
信州大学農学部紀要. 31(1): 45-54 (1994)
departmental bulletin paper
信州大学農学部
1994-08-31
application/pdf
信州大学農学部紀要
1
31
45
54
0583-0621
AN00121352
https://soar-ir.repo.nii.ac.jp/record/10605/files/v31n01_05.pdf
eng