2024-03-29T11:35:28Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00013310
2022-12-14T04:27:33Z
1309:1310
Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery
Kim, Kyu-Oh
Akada, Yaeko
Wei, Kai
Kim, Byoung-Suhk
Kim, Ick-Soo
Self-Assembly
Amphiphilic
Nanoparticles
POSS
Insulin
Oral Delivery
In this work, novel nanostructured core-shell poly (ethylene glycol) (PEG)-polyhedral oligosilsesquioxane (POSS) nanoparticles were used to encapsulate insulin as new drug delivery carriers. The morphologies, particle size and ? potential of th e pure nanostructured core-shell PEG-POSS and th e corresponding insulin-load ed PEG-POSS nanopar-ticles were investigated by transmission electron microscopy (TEM) and laser diffraction particle sizer. TEM analysis demonstrated that pure and insulin-loaded self-assembled PEG-POSS nanoparticles were of spherical shape with core-shell nanostructure, and were well-dispersed and uniform in size distribution. Insulin release test showed that in-sulin was well-protected in side PEG-POSS nanoparticles at gastric pH for 2 hrs, and was released at intestinal pH (pH 6 - 7) where the absorption and activation of the drug are necessary. We therefore believe that such nanostructured PEG-POSS nanoparticles could be useful as a potential carrier for insulin drug delivery systems.
Article
Journal of Biomaterials and Nanobiotechnology. 2:201-206 (2011)
journal article
Scientific Research
2011-07
application/pdf
Journal of Biomaterials and Nanobiotechnology
2
201
206
2158-7027
https://soar-ir.repo.nii.ac.jp/record/13310/files/089_Self-Assembled_Core-Shell_Polye_thylene_glycol-POSS.pdf
eng
10.4236/jbnb.2011.23025
https://doi.org/10.4236/jbnb.2011.23025
Copyright© 2014 by authors and Scientific Research Publishing Inc.