@article{oai:soar-ir.repo.nii.ac.jp:00010265, author = {Karasawa, Koji and Otani, Hajime}, issue = {4}, journal = {JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY}, month = {Aug}, note = {The effects of oral ingestion of a hot water extract of matured fruit of the date palm tree (Phoenix dactylifera L.) on allergic responses were investigated in mite-sensitized mice. Sneezing and nose rubbing events in mice given a date extract-added diet were significantly lower than in those given an extract-free (control) diet. The serum total and mite antigen-specific immunoglobulin (Ig) E levels, and the number of spleen interleukin-4(+)CD4(+), IgE(+)B220(+) and Fc epsilon RI alpha(+)CD117(+) cells was significantly lower in mice given the date extract- added diet than in those given the control diet. Chlorogenic acid, pelargonin and ferulic acid significantly reduced the number of IgE(+)B220(+) cells, while chlorogenic acid and pelargonin significantly decreased the number of Fc epsilon RI alpha(+)CD117(+) cells in mouse spleen cell cultures. These results suggest that some polyphenols in the date may reduce mite-induced allergic symptoms in mice via a decrease in the number of IgE-producing plasma cells and high-affinity IgE receptor-expressing mast cells., Article, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY. 58(4):272-277 (2012)}, pages = {272--277}, title = {Anti-Allergic Properties of a Matured Fruit Extract of the Date Palm Tree (Phoenix dactylifera L.) in Mite-Sensitized Mice}, volume = {58}, year = {2012} }