@article{oai:soar-ir.repo.nii.ac.jp:00010290,
 author = {Shimosato,  Takeshi and Fujimoto,  Megumi and Tohno,  Masanori and Sato,  Takashi and Tateo,  Mariko and Otani,  Hajime and Kitazawa,  Haruki},
 issue = {1},
 journal = {BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS},
 month = {Mar},
 note = {We previously reported the strong immunostimulatory effects of a CpG oligodeoxynucleotide (ODN), designated MsST, from the lacZ gene of Streptococcus (S.) thermophilus ATCC19258. Here we show that 24 h of stimulation with MsST in mouse splenocytes and peritoneal macrophages strongly induces expression of interleukin (IL)-33, a cytokine in the IL-1 superfamily. Other IL-1 superfamily members, including IL-1 alpha, IL-1 beta and IL-18, are down-regulated after 24 h of stimulation of MsST. We also found that MsST-induced IL-33 mRNA expression is inhibited by the suppressive ODN A151, which can inhibit Toll-like receptor 9 (TLR9)-mediated responses. This is the first report to show that IL-33 can be induced by CpG ODNs. The strong induction of IL-33 by MsST suggests that it may be a potential therapeutic ODN for the treatment of inflammatory disease. The presence of a strong CpG ODN in S. thermophilus also suggests that the bacterium may be a good candidate as a starter culture for the development of new physiologically functional foods., Article, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 394(1):81-86 (2010)},
 pages = {81--86},
 title = {CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9},
 volume = {394},
 year = {2010}
}