{"created":"2021-03-01T06:13:10.130486+00:00","id":10290,"links":{},"metadata":{"_buckets":{"deposit":"4fd85a7e-c5c8-4ca2-ad83-9d74c79b4c5c"},"_deposit":{"id":"10290","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10290"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00010290","sets":["1016:1017"]},"author_link":["32551","32552","32553","32554","32555","32556","32557"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"86","bibliographicPageStart":"81","bibliographicVolumeNumber":"394","bibliographic_titles":[{"bibliographic_title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We previously reported the strong immunostimulatory effects of a CpG oligodeoxynucleotide (ODN), designated MsST, from the lacZ gene of Streptococcus (S.) thermophilus ATCC19258. Here we show that 24 h of stimulation with MsST in mouse splenocytes and peritoneal macrophages strongly induces expression of interleukin (IL)-33, a cytokine in the IL-1 superfamily. Other IL-1 superfamily members, including IL-1 alpha, IL-1 beta and IL-18, are down-regulated after 24 h of stimulation of MsST. We also found that MsST-induced IL-33 mRNA expression is inhibited by the suppressive ODN A151, which can inhibit Toll-like receptor 9 (TLR9)-mediated responses. This is the first report to show that IL-33 can be induced by CpG ODNs. The strong induction of IL-33 by MsST suggests that it may be a potential therapeutic ODN for the treatment of inflammatory disease. The presence of a strong CpG ODN in S. thermophilus also suggests that the bacterium may be a good candidate as a starter culture for the development of new physiologically functional foods.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 394(1):81-86 (2010)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Shimosato, Takeshi","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000276474800015"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ACADEMIC PRESS INC ELSEVIER SCIENCE"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"20178773"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/20178773/","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1016/j.bbrc.2010.02.110"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bbrc.2010.02.110","subitem_relation_type_select":"DOI"}}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00564395","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimosato,  Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimoto,  Megumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tohno,  Masanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato,  Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tateo,  Mariko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Otani,  Hajime"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitazawa,  Haruki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-25"}],"displaytype":"detail","filename":"CpG_oligodeoxynucleotides_induce_strong_up-regulation.pdf","filesize":[{"value":"401.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CpG_oligodeoxynucleotides_induce_strong_up-regulation.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/10290/files/CpG_oligodeoxynucleotides_induce_strong_up-regulation.pdf"},"version_id":"9794ef0b-e2b8-4c5b-8b7a-09b4c9f6a425"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"IL-33","subitem_subject_scheme":"Other"},{"subitem_subject":"CpG-ODN","subitem_subject_scheme":"Other"},{"subitem_subject":"TLR9","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-1 superfamily","subitem_subject_scheme":"Other"},{"subitem_subject":"Streptococcus thermophilus","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["1017"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-12-10"},"publish_date":"2012-12-10","publish_status":"0","recid":"10290","relation_version_is_last":true,"title":["CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:13:25.253547+00:00"}