@article{oai:soar-ir.repo.nii.ac.jp:00010291,
 author = {Shimosato,  Takeshi and Tohno,  Masanori and Sato,  Takashi and Nishimura,  Junko and Kawai,  Yasushi and Saito,  Tadao and Kitazawa,  Haruki},
 issue = {5},
 journal = {ANIMAL SCIENCE JOURNAL},
 month = {},
 note = {Immunostimulatory sequences of oligodeoxynucleotides (ODNs), such as CpG ODNs, are potent stimulators of innate immunity. Here, we identified a strong immunostimulatory CpG ODN, which we named MsST, from the lac Z gene of Streptococcus (S.) thermophilus ATCC19258, and we evaluated its immune functions. In in vitro studies, MsST had a similar ability as the murine prototype CpG ODN 1555 to induce inflammatory cytokine production and cell proliferation. In mouse splenocytes, MsST increased the number of CD80+CD11c+and CD86+CD11c+ dendritic cells and CD4+CD25+ regulatory T cells. We also analyzed the effects of MsST on the expression of regulatory cytokines by real-time quantitative PCR. MsST was more potent at inducing interleukin-10 expression than the ODN control 1612, indicating that MsST can augment the regulatory T cell response via Toll-like receptor 9, which plays an important role in suppressing T helper type 2 responses. These results suggest that S. thermophilus, whose genes include a strong Immunostimulatory sequence-ODN, is a good candidate for a starter culture to develop new physiologically functional foods and feeds., Article, ANIMAL SCIENCE JOURNAL. 80(5):597-604 (2009)},
 pages = {597--604},
 title = {Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ},
 volume = {80},
 year = {2009}
}