{"created":"2021-03-01T06:13:10.190285+00:00","id":10291,"links":{},"metadata":{"_buckets":{"deposit":"6dd2b57d-6b1f-40ba-bac6-cb888f995038"},"_deposit":{"id":"10291","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10291"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00010291","sets":["1016:1017"]},"author_link":["32558","32559","32560","32561","32562","32563","32564"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"604","bibliographicPageStart":"597","bibliographicVolumeNumber":"80","bibliographic_titles":[{"bibliographic_title":"ANIMAL SCIENCE JOURNAL"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Immunostimulatory sequences of oligodeoxynucleotides (ODNs), such as CpG ODNs, are potent stimulators of innate immunity. Here, we identified a strong immunostimulatory CpG ODN, which we named MsST, from the lac Z gene of Streptococcus (S.) thermophilus ATCC19258, and we evaluated its immune functions. In in vitro studies, MsST had a similar ability as the murine prototype CpG ODN 1555 to induce inflammatory cytokine production and cell proliferation. In mouse splenocytes, MsST increased the number of CD80+CD11c+and CD86+CD11c+ dendritic cells and CD4+CD25+ regulatory T cells. We also analyzed the effects of MsST on the expression of regulatory cytokines by real-time quantitative PCR. MsST was more potent at inducing interleukin-10 expression than the ODN control 1612, indicating that MsST can augment the regulatory T cell response via Toll-like receptor 9, which plays an important role in suppressing T helper type 2 responses. These results suggest that S. thermophilus, whose genes include a strong Immunostimulatory sequence-ODN, is a good candidate for a starter culture to develop new physiologically functional foods and feeds.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"ANIMAL SCIENCE JOURNAL. 80(5):597-604 (2009)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Shimosato, Takeshi","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000270310300015"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"WILEY-BLACKWELL PUBLISHING, INC"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"20163626"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/20163626/","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1111/j.1740-0929.2009.00680.x"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/j.1740-0929.2009.00680.x","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"The definitive version is available at www.blackwell-synergy.com"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1344-3941","subitem_source_identifier_type":"ISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11677214","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimosato,  Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tohno,  Masanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato,  Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishimura,  Junko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawai,  Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito,  Tadao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitazawa,  Haruki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-25"}],"displaytype":"detail","filename":"Identification_potent_immunostimulatory_oligodeoxynucleotide.pdf","filesize":[{"value":"838.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Identification_potent_immunostimulatory_oligodeoxynucleotide.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/10291/files/Identification_potent_immunostimulatory_oligodeoxynucleotide.pdf"},"version_id":"09957f1a-422b-4065-b136-75fbc94ecaed"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"lacZ","subitem_subject_scheme":"Other"},{"subitem_subject":"ODN","subitem_subject_scheme":"Other"},{"subitem_subject":"regulatory T cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Streptococcus thermophilus","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["1017"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-12-10"},"publish_date":"2012-12-10","publish_status":"0","recid":"10291","relation_version_is_last":true,"title":["Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:13:55.350709+00:00"}