{"created":"2021-03-01T06:13:11.091986+00:00","id":10306,"links":{},"metadata":{"_buckets":{"deposit":"09792f7b-5122-487e-a14b-ba2e1e86225d"},"_deposit":{"id":"10306","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10306"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00010306","sets":["1016:1017"]},"author_link":["32615","32616","32617"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"10","bibliographicPageStart":"7","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study, we investigated the effects of oral ingestion of Saccharomyces (S.) cerevisiae and its specific immunoglobulin (Ig) G-rich fraction, prepared from goat's milk, on immune function in an allergic rhinitis mouse model, ovalbumin (OVA)-sensitized BALB/c mice. Sneezing activity in mice that were administered a feed containing a mixture of S. cerevisiae and its specific goat's milk IgG-rich fraction (mixture group) was significantly lower than that in mice administered the mixture-free feed (control group) at age 11 and 12 weeks, although the activity in mice that were given a feed containing S. cerevisiae (yeast group) was similar to that of the control group. We found that the ratio of spleen interferon-gamma(+)CD4(+) cell/interleukin (IL)-4(+)CD4(+) cell was higher in the mixture and yeast groups than the control group. The number of spleen CD80(+)CD11b(+) cells was significantly lower in the mixture and yeast groups than the control group. In contrast, the numbers of spleen CD122(+)CD8 alpha(+) and IL-10(+)CD4(+) cells were significantly higher in the mixture group than the control and yeast groups while the numbers of IgE(+)B220(+) and Fc epsilon RI alpha(+)CD117(+) cells were significantly lower in the mixture group. These results suggested that the mixture of S. cerevisiae and its specific goat's milk IgG-rich fraction reduced OVA-induced allergic symptoms in BALB/c mice via the induction of suppressor T cells and the reduction of Ig E-producing cells and high affinity IgE receptor-positive mast cells rather than the adjustment of the Th1/Th2 balance.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL. 66(1): 7-10(2011)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Shimosato, Takeshi","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_text":"Web of Science","subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000287643600002"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"A V A AGRARVERLAG"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0026-3788","subitem_source_identifier_type":"ISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00285427","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sekekimura,  Yumi"}],"nameIdentifiers":[{"nameIdentifier":"32615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimosato,  Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"32616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Otani,  Hajime"}],"nameIdentifiers":[{"nameIdentifier":"32617","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-25"}],"displaytype":"detail","filename":"Anti-allergic_effects_mixture_Saccharomyces.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Anti-allergic_effects_mixture_Saccharomyces.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/10306/files/Anti-allergic_effects_mixture_Saccharomyces.pdf"},"version_id":"9b37d716-ef16-48d8-9044-6582a242b5a9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"14 Allergy","subitem_subject_scheme":"Other"},{"subitem_subject":"14 Allergie","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse model","subitem_subject_scheme":"Other"},{"subitem_subject":"Mausmodell","subitem_subject_scheme":"Other"},{"subitem_subject":"antiallergic effects","subitem_subject_scheme":"Other"},{"subitem_subject":"antiallergische Effekte","subitem_subject_scheme":"Other"},{"subitem_subject":"Saccharomyces cerevisiaelgoal's milk","subitem_subject_scheme":"Other"},{"subitem_subject":"Saccharomyces cerevisiaelZiegenmilch-lgG","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat's milk immunoglobulin G rich fraction on ovalbumin sensitized BALB/c mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat's milk immunoglobulin G rich fraction on ovalbumin sensitized BALB/c mice","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["1017"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-06-20"},"publish_date":"2011-06-20","publish_status":"0","recid":"10306","relation_version_is_last":true,"title":["Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat's milk immunoglobulin G rich fraction on ovalbumin sensitized BALB/c mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:14:11.770197+00:00"}