{"created":"2021-03-01T06:13:13.813772+00:00","id":10351,"links":{},"metadata":{"_buckets":{"deposit":"2024d407-897d-4a29-bc46-32941fade9d4"},"_deposit":{"id":"10351","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10351"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00010351","sets":["1016:1017"]},"author_link":["32753","32754"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"433","bibliographicPageStart":"428","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"An immunostimulating glutamine-rich peptide was purified from a soybean protein fraction digested with Peptidase R produced by Rhizopus oryzae (Ro-digest) by a combination of SP-Sepharose column chromatography and reversed-phase high-performance liquid chromatography. The purified peptide was supposed to be located at or near the glutamine-rich region 202 to 222 of the glycinin G4 subunit. The peptide significantly increased the number of CD8(+), CD11b(+), and CD49b(+) cells in C3H/HeN mouse spleen cell cultures, while 2 chemically synthesized glutamine-rich peptides corresponding to residues 202 to 213 (QQQQQQKSHGGR) and residues 214 to 225 (KQGQHQQEEEEE) of the glycinin G4 subunit increased the number of interleukin (IL)-12(+)CD11b(+) cells. The peptide 202-213 also significantly increased the number of CD49b(+), IL-2(+)CD4(+), and interferon-gamma(+)CD4(+) cells and stimulated the cytotoxic activity of spleen cells toward the human erythroleukemia cell line K562. These results indicate that the glutamine-rich region of the soybean glycinin G4 subunit stimulates the cellular immune system in mouse spleen cell cultures.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY","subitem_description_type":"Other"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000271305900008"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"CENTER ACADEMIC PUBL JAPAN"}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.3177/jnsv.55.428"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3177/jnsv.55.428","subitem_relation_type_select":"DOI"}}]},"item_6_relation_51":{"attribute_name":"異版である","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/10025972201/","subitem_relation_type_select":"URI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2009 by the Center for Academic Publications Japan"},{"subitem_rights":"日本ビタミン学会, 日本栄養・食糧学会"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0301-4800","subitem_source_identifier_type":"ISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00703822","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Egusa,  Shintaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Otani,  Hajime"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-25"}],"displaytype":"detail","filename":"characterization_cellular_immunostimulating_Peptide.pdf","filesize":[{"value":"623.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"characterization_cellular_immunostimulating_Peptide.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/10351/files/characterization_cellular_immunostimulating_Peptide.pdf"},"version_id":"78079a6e-a199-4216-a3b8-d4b191edf7ba"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"glycinin G4","subitem_subject_scheme":"Other"},{"subitem_subject":"Peptidase R","subitem_subject_scheme":"Other"},{"subitem_subject":"cellular immunostimulation","subitem_subject_scheme":"Other"},{"subitem_subject":"glutamine-rich peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"cytotoxic activity","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Characterization of a Cellular Immunostimulating Peptide from a Soybean Protein Fraction Digested with Peptidase R","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Characterization of a Cellular Immunostimulating Peptide from a Soybean Protein Fraction Digested with Peptidase R","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["1017"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-11-15"},"publish_date":"2010-11-15","publish_status":"0","recid":"10351","relation_version_is_last":true,"title":["Characterization of a Cellular Immunostimulating Peptide from a Soybean Protein Fraction Digested with Peptidase R"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:41:16.448608+00:00"}