@article{oai:soar-ir.repo.nii.ac.jp:00010352,
 author = {Ohashi,  Yuki and Uchida,  Kenji and Kawasaki,  Mihoko and Otani,  Hajime},
 issue = {1},
 journal = {MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL},
 month = {Oct},
 note = {Five-week-old male mice were divided into 2 groups in which they were orally given sterile saline solution (control solution) or cow's colostrum powder prepared from milk produced 6 to 7 days after parturition in sterile saline solution (colostrum solution). The mice were given the solution once a day for 5 weeks. The level of intestinal total IgG was significantly lower in the mice given the colostrum solution than in the mice given the control solution, and the intestinal IgA and serum IgG levels tended to be lower in the mice given the colostrum solution. The numbers of spleen CD11b(+), CD19(+), and IFN-gamma(+)CD4(+) cells were also significantly lower in mice given the colostrum solution. DNA microarray analysis of mRNAs extracted from Peyer's patch cells showed that the gene expression of proteins relating to T cell activation of acquired immune responses or Fc epsilon-mediated mast cell activation was obviously lower in the mice given the colostrum solution than in the mice given the control solution, whereas that of proteins relating to T regulatory cells or intestinal innate immune system was noticeably higher in mice given the colostrum solution. These results suggest that the oral ingestion of cow's colostrum suppresses the acquired immune system and type I allergic reactions, and enhances the innate immune system., Article, MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL. 65(1):11-15 (2010)},
 pages = {11--15},
 title = {The effect on mouse immune systems of cow's colostrum produced 6 to 7 days after parturition},
 volume = {65},
 year = {2010}
}