{"_buckets": {"deposit": "ab2f57fa-13d0-40aa-a57a-168ab4861e3e"}, "_deposit": {"id": "10435", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "10435"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00010435", "sets": ["1017"]}, "author_link": ["33022", "33023", "33024", "33025", "33026", "33027", "33028"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "789", "bibliographicPageStart": "783", "bibliographicVolumeNumber": "72", "bibliographic_titles": [{"bibliographic_title": "Applied microbiology and biotechnology"}]}]}, "item_6_description_19": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "The original publication is available at www.springerlink.com.", "subitem_description_type": "Other"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Applied Microbiology and Biotechnology. 72(4): 783-789 (2006)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Ikeda, M", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.uhLNPUkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000240809600022"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "SPRINGER"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "16944136"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/16944136/", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s00253-006-0539-7"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s00253-006-0539-7", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0175-7598", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0175-7598", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10503386", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "Cornynebacterium glutamicum; L-lysine; fermentation; DNA array"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "TRANSCRIPTOME ANALYSIS; (P)PPGPP METABOLISM; PLASMID DNA; MUTANT; ACID; STRAIN; TRANSFORMATION; BIOSYNTHESIS; FAMILY; EXPORT"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "We previously found by transcriptome analysis that global induction of amino acid biosynthetic genes occurs in a classically derived industrial L-lysine producer, Corynebacterium glutamicum B-6. Based on this stringent-like transcriptional profile in strain B-6, we analyzed the relevant mutations from among those identified in the genome of the strain, with special attention to the genes that are involved in amino acid biosynthesis and metabolism. Among these mutations, a Gly-456 -\u003e Asp mutation in the 3-isopropylmalate dehydratase large subunit gene (leuC) was defined as a useful mutation. Introduction of the leuC mutation into a defined L-lysine producer, AHD-2 (hom59 and lysC311), by allelic replacement led to the phenotype of a partial requirement for L-leucine and approximately 14% increased L-lysine production. Transcriptome analysis revealed that many amino acid biosynthetic genes, including lysC-asd operon, were significantly upregulated in the leuC mutant in a rel-independent manner."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hayashi,  M"}], "nameIdentifiers": [{"nameIdentifier": "33022", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizoguchi,  H"}], "nameIdentifiers": [{"nameIdentifier": "33023", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohnishi,  J"}], "nameIdentifiers": [{"nameIdentifier": "33024", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mitsuhashi,  S"}], "nameIdentifiers": [{"nameIdentifier": "33025", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yonetani,  Y"}], "nameIdentifiers": [{"nameIdentifier": "33026", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashimoto,  S"}], "nameIdentifiers": [{"nameIdentifier": "33027", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikeda,  M"}], "nameIdentifiers": [{"nameIdentifier": "33028", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "A leuC mutation.pdf", "filesize": [{"value": "726.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 726100.0, "url": {"label": "A leuC mutation.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/10435/files/A leuC mutation.pdf"}, "version_id": "47b591e0-5f3d-4b90-b373-d15c4a6e4c39"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "A leuC mutation leading to increased L-lysine production and rel-independent global expression changes in Corynebacterium glutamicum", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "A leuC mutation leading to increased L-lysine production and rel-independent global expression changes in Corynebacterium glutamicum", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["1017"], "permalink_uri": "http://hdl.handle.net/10091/199", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-05-07"}, "publish_date": "2007-05-07", "publish_status": "0", "recid": "10435", "relation": {}, "relation_version_is_last": true, "title": ["A leuC mutation leading to increased L-lysine production and rel-independent global expression changes in Corynebacterium glutamicum"], "weko_shared_id": -1}