{"_buckets": {"deposit": "2651a6c9-ab4e-4185-be89-f4df61b2c0db"}, "_deposit": {"id": "10440", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "10440"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00010440", "sets": ["1017"]}, "author_link": ["33051", "33052", "33053", "33054", "33055", "33056", "33057", "33058", "33059", "33060", "33061", "33062", "33063"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1-2", "bibliographicPageEnd": "141", "bibliographicPageStart": "133", "bibliographicVolumeNumber": "276", "bibliographic_titles": [{"bibliographic_title": "MOLECULAR AND CELLULAR BIOCHEMISTRY"}]}]}, "item_6_description_19": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "The original publication is available at www.springerlink.com.", "subitem_description_type": "Other"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "MOLECULAR AND CELLULAR BIOCHEMISTRY. 276(1-2): 133-141 (2005)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Takagi, Y", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.yNTUPpkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000231220500017"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "SPRINGER"}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s11010-005-3673-0"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s11010-005-3673-0", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0300-8177", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0300-8177", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00745800", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "adipogenin; adipogenesis; GNF SymAtlas; high-fat diet"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "ADIPOSE-TISSUE; ENERGY-BALANCE; PPAR-GAMMA; DIFFERENTIATION; OBESITY; TRANSCRIPTOMES; PPAR-GAMMA-2; ADIPONUTRIN; CONVERSION; EXPRESSION"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Until now, the various proteins highly expressed in adipose tissues have been identified and characterized by traditional gene cloning techniques. However, methods of computer analysis have been developed to compare the levels of expression among various tissues, and genes whose expression levels differ significantly between tissues have been found. Among these genes, we report on the possible function of a new adipose-specific gene, showed higher expression in adipose tissue through \u0027Search Expression\u0027 on Genome Institute of Norvartis Research Foundation (GNF) SymAtlas v0.8.0. This database has generated and analyzed gene expression of each gene in diverse samples of normal tissues, organs, and cell lines. This newly discovered gene product was named adipogenin because of its role in stimulating adipocyte differentiation and development. Adipogenin mRNA was highly expressed in four different fat depots, and exclusively expressed in adipocytes isolated from adipose tissues. The level of adipogenin mRNA was up-regulated in the subcutaneous and visceral adipose tissues of mice fed a high-fat diet compared to those on the control diet. The expression of adipogenin mRNA is dramatically elevated during adipocyte differentiation of 3T3-L1 cells. Troglitazone, which up-regulated peroxisome proliferators-activated receptor gamma 2 (PPAR-gamma 2) expression, increased adipogenin mRNA expression, although this gene was down-regulated by retinoic acid. Confocal image analyses of green-fluorescent protein-adipogenin (pEGFP-adipogenin) transiently expressed in 3T3-L1 adipocytes showed that adipogenin was strictly localized to membranes and was absent from the cytosol. Moreover, small interfering RNA (siRNA) mediated a reduction of adipogenin mRNA in 3T3-L1 cells and blocked the process of adipocyte differentiation. These results indicate that adipogenin, an adipocyte-specific membrane protein, may be involved with adipogenesis, as one of the regulators of adipose tissue development."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hong,  YH"}], "nameIdentifiers": [{"nameIdentifier": "33051", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hishikawa,  D"}], "nameIdentifiers": [{"nameIdentifier": "33052", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyahara,  H"}], "nameIdentifiers": [{"nameIdentifier": "33053", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuzuki,  H"}], "nameIdentifiers": [{"nameIdentifier": "33054", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishimura,  Y"}], "nameIdentifiers": [{"nameIdentifier": "33055", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Gotoh,  C"}], "nameIdentifiers": [{"nameIdentifier": "33056", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Choi,  KC"}], "nameIdentifiers": [{"nameIdentifier": "33057", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hokari,  Y"}], "nameIdentifiers": [{"nameIdentifier": "33058", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takagi,  Y"}], "nameIdentifiers": [{"nameIdentifier": "33059", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lee,  HG"}], "nameIdentifiers": [{"nameIdentifier": "33060", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Cho,  KK"}], "nameIdentifiers": [{"nameIdentifier": "33061", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Roh,  SG"}], "nameIdentifiers": [{"nameIdentifier": "33062", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki,  S"}], "nameIdentifiers": [{"nameIdentifier": "33063", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Roh.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "Roh.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/10440/files/Roh.pdf"}, "version_id": "6941b7ef-9299-4f50-8f14-a918f6acd1fb"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Up-regulation of adipogenin, an adipocyte plasma transmembrane protein, during adipogenesis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Up-regulation of adipogenin, an adipocyte plasma transmembrane protein, during adipogenesis", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["1017"], "permalink_uri": "http://hdl.handle.net/10091/187", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-04-25"}, "publish_date": "2007-04-25", "publish_status": "0", "recid": "10440", "relation": {}, "relation_version_is_last": true, "title": ["Up-regulation of adipogenin, an adipocyte plasma transmembrane protein, during adipogenesis"], "weko_shared_id": -1}