{"created":"2021-03-01T06:13:29.277099+00:00","id":10605,"links":{},"metadata":{"_buckets":{"deposit":"1ecdd7e8-5411-4aed-904a-1838995a91c9"},"_deposit":{"id":"10605","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10605"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00010605","sets":["1016:1018:1019:1040"]},"author_link":["33514","33515","33516","33517"],"item_10_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Ｎ置換グルコサミン誘導体の合成とそれらのアンジオテンシン I 変換酵素阻害能","subitem_alternative_title_language":"ja"}]},"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-08-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"54","bibliographicPageStart":"45","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"信州大学農学部紀要"}]}]},"item_10_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Inhibitory activity of glucosamine derivatives against angiotensin I converting enzyme (ACE) was investigated. Many N-substituted glucosamine derivatives were synthesized via 1,3,4,6-tetra-O-acetyl-glucosamine hydrochloride. Among them, N-(phenylalanyl-alanyl-prolyl)-glucosamine was found to be the most effective for ACE inhibition, and the half inhibitory concentrations (IC50_) was estimated as 300μM. Furthermore, N-(3,7-dimethyl-2(E/Z), 6-hexadien-carbonyl)-glucosamine and N-(p-dimethylamino benzoyl)-glucosamine were found to be effective for the inhibition of ACE, and their IC50 values were estimated as 5 mM and 8 mM, respectively.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_10_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"信州大学農学部紀要. 31(1): 45-54 (1994)","subitem_description_type":"Other"}]},"item_10_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"信州大学農学部"}]},"item_10_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0583-0621","subitem_source_identifier_type":"ISSN"}]},"item_10_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00121352","subitem_source_identifier_type":"NCID"}]},"item_1627890569677":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawakami,  A"}],"nameIdentifiers":[{"nameIdentifier":"33514","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kayahara,  H"}],"nameIdentifiers":[{"nameIdentifier":"33515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ajiro,  H"}],"nameIdentifiers":[{"nameIdentifier":"33516","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tadasa,  K"}],"nameIdentifiers":[{"nameIdentifier":"33517","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-25"}],"displaytype":"detail","filename":"v31n01_05.pdf","filesize":[{"value":"421.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"v31n01_05.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/10605/files/v31n01_05.pdf"},"version_id":"ef2295be-5512-4e0b-8848-8d37013e6861"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"glucosamine","subitem_subject_scheme":"Other"},{"subitem_subject":"Angiotensin I converting enzyme","subitem_subject_scheme":"Other"},{"subitem_subject":"inhibitor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synthesis of N-Substituted Glucosamine Derivatives and Their Angiotensin I Converting Enzyme Inhibitory Activity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis of N-Substituted Glucosamine Derivatives and Their Angiotensin I Converting Enzyme Inhibitory Activity","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["1040"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-12-28"},"publish_date":"2007-12-28","publish_status":"0","recid":"10605","relation_version_is_last":true,"title":["Synthesis of N-Substituted Glucosamine Derivatives and Their Angiotensin I Converting Enzyme Inhibitory Activity"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-06T02:08:49.355716+00:00"}