{"created":"2021-03-01T06:13:29.277099+00:00","id":10605,"links":{},"metadata":{"_buckets":{"deposit":"1ecdd7e8-5411-4aed-904a-1838995a91c9"},"_deposit":{"id":"10605","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10605"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00010605"},"item_10_alternative_title_1":{"attribute_name":"\u305d\u306e\u4ed6\uff08\u5225\u8a00\u8a9e\u7b49\uff09\u306e\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_alternative_title":"\uff2e\u7f6e\u63db\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u8a98\u5c0e\u4f53\u306e\u5408\u6210\u3068\u305d\u308c\u3089\u306e\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3 I \u5909\u63db\u9175\u7d20\u963b\u5bb3\u80fd"}]},"item_10_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-08-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"54","bibliographicPageStart":"45","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"\u4fe1\u5dde\u5927\u5b66\u8fb2\u5b66\u90e8\u7d00\u8981"}]}]},"item_10_description_20":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"Inhibitory activity of glucosamine derivatives against angiotensin I converting enzyme (ACE) was investigated. Many N-substituted glucosamine derivatives were synthesized via 1,3,4,6-tetra-O-acetyl-glucosamine hydrochloride. Among them, N-(phenylalanyl-alanyl-prolyl)-glucosamine was found to be the most effective for ACE inhibition, and the half inhibitory concentrations (IC50_) was estimated as 300\u03bcM. Furthermore, N-(3,7-dimethyl-2(E/Z), 6-hexadien-carbonyl)-glucosamine and N-(p-dimethylamino benzoyl)-glucosamine were found to be effective for the inhibition of ACE, and their IC50 values were estimated as 5 mM and 8 mM, respectively.","subitem_description_type":"Abstract"}]},"item_10_description_30":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_10_description_5":{"attribute_name":"\u5f15\u7528","attribute_value_mlt":[{"subitem_description":"\u4fe1\u5dde\u5927\u5b66\u8fb2\u5b66\u90e8\u7d00\u8981. 31(1): 45-54 (1994)","subitem_description_type":"Other"}]},"item_10_publisher_4":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"\u4fe1\u5dde\u5927\u5b66\u8fb2\u5b66\u90e8"}]},"item_10_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0583-0621","subitem_source_identifier_type":"ISSN"}]},"item_10_source_id_40":{"attribute_name":"\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00121352","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawakami,  A"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kayahara,  H"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ajiro,  H"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tadasa,  K"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-25"}],"displaytype":"detail","filename":"v31n01_05.pdf","filesize":[{"value":"421.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"v31n01_05.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/10605/files/v31n01_05.pdf"},"version_id":"ef2295be-5512-4e0b-8848-8d37013e6861"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"glucosamine","subitem_subject_scheme":"Other"},{"subitem_subject":"Angiotensin I converting enzyme","subitem_subject_scheme":"Other"},{"subitem_subject":"inhibitor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synthesis of N-Substituted Glucosamine Derivatives and Their Angiotensin I Converting Enzyme Inhibitory Activity","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"Synthesis of N-Substituted Glucosamine Derivatives and Their Angiotensin I Converting Enzyme Inhibitory Activity"}]},"item_type_id":"10","owner":"1","path":["1016/1018/1019/1040"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2007-12-28"},"publish_date":"2007-12-28","publish_status":"0","recid":"10605","relation_version_is_last":true,"title":["Synthesis of N-Substituted Glucosamine Derivatives and Their Angiotensin I Converting Enzyme Inhibitory Activity"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2021-03-01T12:08:19.513975+00:00"}