@article{oai:soar-ir.repo.nii.ac.jp:00010691, author = {SHIBATA, Hisao and HASEGAWA, Taizo and KAYAHARA, Hiroshi}, issue = {2}, journal = {信州大学農学部紀要}, month = {Jan}, note = {Protease inhibitor, pepstatin is a pentapeptide which involves two unusual amino acid, statine (3S-hydroxy-4S-amino-6-methylheptanoic acid (I)). Pepstatin is known to inhibit renin in the hypertensive renin-angiotensin system and shown to suppress blood pressure strongly. The present paper deals with the simple and convenient synthesis of butyl 1-p-menthen-3-azido-4-hydroxy-7-carboxy late (III) in which III is one of the important intermediate leading to the isosteric isomer of statin, namely, p-menthan-3-amino-2-hydroxy-7-carboxylic acid (II). Further, the acid-catalysed isomerization is also discussed., Article, 信州大学農学部紀要 24(2): 141-146(1988)}, pages = {141--146}, title = {Synthesis of Butyl 1-p-Menthene-3-A.zido-4-Hydroxy-7-Carboxylate, the Synthetic Intermediate of Statine Analogue}, volume = {24}, year = {1988} }