@article{oai:soar-ir.repo.nii.ac.jp:00010718,
 author = {辻井,  弘忠},
 issue = {1},
 journal = {信州大学農学部紀要},
 month = {Jul},
 note = {Indomethacin was an inhibitor of prostaglandin synthesis. Kennedy (1977), Phillips and Poyser (1981) reported that the indomethacin administration in rats during early pregnancy caused a delay in implantation. However, they did not flush the uterine horns and the study group were implanted on the 6 th day of pregnancy according to uterin dye sites. The purpose of this study is to determine whether or not embryos recover from delayed implantation when treated with indomethacin. Wistar rats were housed under temperature- and light-controlled conditions (lights on 06:00-18:00 hr) with free access to food and water. All rats used had demonstrated regular 4-day cycles. The Pontamine Sky Blue dye was injected into the which vein under anaesthesis. The rats were sacrificed 15 min. later and examined for 'dye reaction' sites. The uterine horns were flushed with K. R. P. The uterine 'dye reaction' sites were indicative of the implantation sites. Exp 1, the rats were injected s. c. with indomethacin 3 mg/kg at 9:00 h and 17:00 h on day 3 and 4 of pregnancy as described by Phillips and Poyser. Exp 2-6, the rats were injected s. c. with indomethacin 2 mg at 9:00 h on day 5 of pregnancy. According to the results, the rats demonstrated implantation in the uterine horn on the 6 day of pregnancy with uterine dye sites. A few delayed implanted blas-tocysts were recovered from uterine horns (Table 1-4). The recovered embryos were abnormal in form (Fig. 3-6) compared with the ovariectomized, progesterone-treated rat (Fig. 1). The length of pregnancy was slightly but significantly longer in the single dose indomethacin treated rats (Table 6). Indomethacin administration produced a significant effect on the proportion of rats with uterine dye sites, litter size and birth weight (Table 4 and 6). Therefore indomethacin effect may be mediated by inhibition of ovarian steroidogenesis and increase in the permeability of endometrial capillaries at the blastocyst implantation sites., Article, 信州大学農学部紀要 21(1): 49-58(1984)},
 pages = {49--58},
 title = {インドメサチンによるラット着床遅延卵子について},
 volume = {21},
 year = {1984}
}