{"created":"2021-03-01T06:13:47.019328+00:00","id":10897,"links":{},"metadata":{"_buckets":{"deposit":"77314ad5-0b9d-49e9-8237-08b589bbedcd"},"_deposit":{"id":"10897","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10897"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00010897","sets":["1016:1018:1019:1067"]},"author_link":["34164","34165"],"item_10_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"乳汁および血清成分の抗原性およびその比較検討","subitem_alternative_title_language":"ja"}]},"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1967-09-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"198","bibliographicPageStart":"181","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"信州大学農学部紀要"}]}]},"item_10_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It is quite possible that immunological and immunochemical analysis, which are more sensitive and more specific detection methods for macromolecular substances, were of great use as comparative re-examination of the fractions of milk obtained by chemical methods. This paper reports preliminary observations on the antigenicities and their relationship of human and bovine milk and blood sera by means of in-gel and immune electrophoresis. 1). It is the most effective condition for the production of antibodies that the rabbits were hyperimmunized intramuscularly with milk whey protein and blood serum which were prepared with Complete Freund's Adjuvant (Adjuvant II). 2). Immunological analysis by double diffusion method had revealed the several kinds of antigenic substances in bovine milk (BM), bovine serum (BS), human milk (HM) and human serum (HS). Some of these milk substances were found to be immunologically related to blood serum substances, especially, at least one of identifiable substances was found between BM and BS or HM and HS respectively. No immunologically relations, however, were found between BM and HM, BM and HS, HM and BS or HS and BS by the method. 3). From the immune electrophoretical precipitation patterns, it has been found that large number of antigenic substances are contained in both human blood serum and bovine blood serum, and that the spectrum of human-serum-anti-human serum is nearly similar to that of bovine serum-anti-bovine serum. It has not been cleared, however, whether both of them are serologically identical or not. 4). In human milk, thirteen separate antigenic substances were recognized, at least eight or nine of which were found to be identical or closely related to these in human blood serum proteins. On the other hand, twelve separate antigenic substances in bovine milk were recognized, at least six of these were to be serologically related to bovine blood serum proteins. 5). No precipitation lines were also found in the human milk-anti-bovine milk, human milk-anti-bovine serum, human serum-anti-bovine milk, human serum-anti-bovine serum, bovine milk-anti-human milk, bovine milk-anti-human serum, bovine serum-anti-human milk and bovine serum-anti-human serum spectra by immune electrophoresis. No immunological relations, in other words, were recognized between human source antigens and bovine source antigens. 6). Bovine milk protein fractions which were prepared with various chemical methods were immunologically examined against anti-bovine milk serum. The three different antigenic factors were observed in alpha-casein and immune globulin. On human milk protein fractions, however, one dense precipitation lines were recognized on the each fractions against anti-human milk serum. 7). DEAE-cellulose column chromatogram of human milk were apparently differed from these of bovine milk. It was found that the each fraction of the chromatograms was not always one antigenic factor by immune electrophoresis.","subitem_description_type":"Abstract"}]},"item_10_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_10_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"信州大学農学部紀要 4(2): 181-198(1967)","subitem_description_type":"Other"}]},"item_10_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"信州大学農学部"}]},"item_10_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0583-0621","subitem_source_identifier_type":"ISSN"}]},"item_10_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00121352","subitem_source_identifier_type":"NCID"}]},"item_1627890569677":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TOKITA,  Fumisaburo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKAHASHI,  Fujio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-25"}],"displaytype":"detail","filename":"Agriculture04-02-07.pdf","filesize":[{"value":"804.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Agriculture04-02-07.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/10897/files/Agriculture04-02-07.pdf"},"version_id":"b0ce80dc-b895-4f79-bdae-6cf2e2dae09d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Antigenicities of Human and Bovine Raw Milk and Blood Sera, and these Comparative Analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antigenicities of Human and Bovine Raw Milk and Blood Sera, and these Comparative Analysis","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["1067"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-03-03"},"publish_date":"2009-03-03","publish_status":"0","recid":"10897","relation_version_is_last":true,"title":["Antigenicities of Human and Bovine Raw Milk and Blood Sera, and these Comparative Analysis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-23T06:43:03.956237+00:00"}