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The 2-methylthio group in these Spiro compounds was easily replaced with some primary and secondary amines to afford the corresponding 2-amino derivatives. Very interestingly, the proton signals of these Spiro compounds in the H-1-NMR spectra in deuteriochloroform (CDCl3) changed with an increase in the sample concentration, and the analysis for the magnitude and the direction of each proton shift disclosed the conformational change of the cyclopentenone moiety in this molecule.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\uff1amime\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "HETEROCYCLES. 81(9):2075-2086 (2010)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Suga, Hiroyuki", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.HmShyVfp.html"}, {"subitem_link_text": "Okumura, Yukihisa", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.gNDVgpAF.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000282865300005"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "The Japan Institute of Heterocyclic Chemistry"}]}, "item_6_relation_46": {"attribute_name": "\u4ed6\u306e\u8cc7\u6e90\u3068\u306e\u95a2\u4fc2\uff1aURI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://www.heterocycles.jp/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.heterocycles.jp/", "subitem_relation_type_select": "URI"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.3987/COM-10-11985"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.3987/COM-10-11985", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "Copyright\u00a9 2010 The Japan Institute of Heterocyclic Chemistry"}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0385-5414", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0385-5414", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00663739", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "Imidazo[1,2-a]pyridine; Spiro[2-cyclopentene-1,3 \u0027-imidazo[1,2-a]pyridine]; Synthesis; Concentration Dependency of Proton Signal; X-Ray Analysis"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "IMPAIRMENT; ZSET1446; MEMORY"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Ethyl 2\u0027,3\u0027-dihydro-2-methylthio-2\u0027,4-dioxospiro[2-cyclopentene-1,3\u0027-imidazo[1,2-a]pyridine]-3-carboxylates were synthesized from the reactions of 3-[bis(methylthio)methylene]-2(3H)-imidazo[1,2-a]pyridinones with ethyl 4-chloroacetoacetate in the presence of a base. The 2-methylthio group in these Spiro compounds was easily replaced with some primary and secondary amines to afford the corresponding 2-amino derivatives. Very interestingly, the proton signals of these Spiro compounds in the H-1-NMR spectra in deuteriochloroform (CDCl3) changed with an increase in the sample concentration, and the analysis for the magnitude and the direction of each proton shift disclosed the conformational change of the cyclopentenone moiety in this molecule."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Abe,  Takashi"}], "nameIdentifiers": [{"nameIdentifier": "38186", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kakehi,  Akikazu"}], "nameIdentifiers": [{"nameIdentifier": "38187", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suga,  Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "38188", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okumura,  Yukihisa"}], "nameIdentifiers": [{"nameIdentifier": "38189", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Itoh,  Kennosuke"}], "nameIdentifiers": [{"nameIdentifier": "38190", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "SYNTHESIS_SPIRO_DERIVATIVES.pdf", "filesize": [{"value": "187.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 187200.0, "url": {"label": "SYNTHESIS_SPIRO_DERIVATIVES.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/12509/files/SYNTHESIS_SPIRO_DERIVATIVES.pdf"}, "version_id": "27770638-5f05-4829-8553-38f5b6f26c8c"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Imidazo[1,2-a]pyridine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Spiro[2-cyclopentene-1,3\u2019-imidazo[1,2-a]pyridine]", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Synthesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Concentration Dependency of Proton Signal", "subitem_subject_scheme": "Other"}, {"subitem_subject": "X-Ray Analysis", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Synthesis of Spiro[2-cyclopentene-1,3\u2019-imidazo[1,2-a]pyridine] Derivatives and Their Interesting Behavior in 1H-NMR Spectra in Deuteriochloroform", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Synthesis of Spiro[2-cyclopentene-1,3\u2019-imidazo[1,2-a]pyridine] Derivatives and Their Interesting Behavior in 1H-NMR Spectra in Deuteriochloroform"}]}, "item_type_id": "6", "owner": "1", "path": ["1221/1222"], "permalink_uri": "http://hdl.handle.net/10091/10742", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2010-10-27"}, "publish_date": "2010-10-27", "publish_status": "0", "recid": "12509", "relation": {}, "relation_version_is_last": true, "title": ["Synthesis of Spiro[2-cyclopentene-1,3\u2019-imidazo[1,2-a]pyridine] Derivatives and Their Interesting Behavior in 1H-NMR Spectra in Deuteriochloroform"], "weko_shared_id": null}