{"created":"2021-03-01T06:15:27.867259+00:00","id":12551,"links":{},"metadata":{"_buckets":{"deposit":"023cd686-c70c-4713-8f9c-6b7c98552e67"},"_deposit":{"id":"12551","owners":[],"pid":{"revision_id":0,"type":"depid","value":"12551"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00012551","sets":["1221:1222"]},"author_link":["38332","38333"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Novel 3D protein structural homology search algorithm based on the Triangle ID"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"56","bibliographicPageStart":"44","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Journal of Computer Aided Chemistry"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ポストゲノムの近年、タンパク質の立体構造データの登録数が飛躍的に増加している。タンパク質を構成しているアミノ酸の配列に基づく類似性検索では見つからない立体的に類似している遠縁ホモログが見つかっており、タンパク質の立体構造の類似性（ホモロジー）検索が求められている。我々は、新規な三角形IDに基づくタンパク質立体構造ホモロジー検索の可能性について検討を行った。三角形IDとは、辺の長さに幅を持たせた三頂点20種類のアミノ酸の組み合わせ8000個の数値IDである。タンパク質のアミノ酸Cαの位置関係を三角形に見立て、該当する三角形IDにすべて数値変換し、その三角形IDを比較する方法である。本手法の有効性を示すために、立体構造的に類似しているタンパク質のセリンプロテアーゼファミリとそれと異なるファミリのタンパク質を用いて検証用データセットを作成した。そしてセリンプロテアーゼファミリであるヒトのトロンビンを検索式に、同じセリンプロテアーゼファミリのヒトとウシのトロンビン、ファクターXa、トリプシン、そして異なるファミリのHIV-1プロテアーゼ、PTP1B を含む58個の検証用データセットに対して三角形IDに基づくタンパク質立体構造ホモロジー検索を行った。その結果、類似度の高い順から、ヒトのトロンビン、ウシのトロンビン、そして同じセリンプロテアーゼファミリであるファクターXa、トリプシンがその次ぎに続き、下位にセリンプロテアーゼと異なるHIV-1プロテアーゼ、PTP1Bとなり、三角形IDに基づくタンパク質立体構造ホモロジー検索の可能性を示した。","subitem_description_type":"Abstract"},{"subitem_description":"In the post-genome era, the number of registered 3D protein structures increases dramatically.BLAST homology search tool is widely used for finding homologues. However, there are many remotehomologue proteins with 3D structural similarity that BLAST cannot detect. Accordingly 3D proteinstructural homology search is strongly required. We propose a novel 3D protein structural homologysearch algorithm based on the Triangle ID comparison method. We focused a triangle structure consistingof three amino acids and called it as Triangle ID. We considered 20 kinds of amino acids, so there are8000 kinds of Triangle IDs. We assumed that proteins can be characterized by using these Triangle IDs.To prove the validness of this assumption, we developed the homology search tool and made severalsample data sets that consist of serine protease family and different family from serine protease. Usingthese data, we did several search experiments and showed the validness of our assumption and thescalability of our method. Our method opens the possibility of the efficient 3D protein structuralhomology search.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Computer Aided Chemistry. 6:44-56 (2005)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"海尻, 賢二","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.gFypZVkh.html"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"社団法人日本化学会"}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.2751/jcac.6.44"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2751/jcac.6.44","subitem_relation_type_select":"DOI"}}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1345-8647","subitem_source_identifier_type":"ISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12022560","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"丸山,  英俊"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"海尻,  賢二"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-28"}],"displaytype":"detail","filename":"6_44.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6_44.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/12551/files/6_44.pdf"},"version_id":"8fd4b33b-d017-412d-9593-b756a4a3454f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"タンパク質立体構造ホモロジー検索","subitem_subject_scheme":"Other"},{"subitem_subject":"三角形ID","subitem_subject_scheme":"Other"},{"subitem_subject":"近傍三角形ID","subitem_subject_scheme":"Other"},{"subitem_subject":"タンパク質三次元構造","subitem_subject_scheme":"Other"},{"subitem_subject":"PDB","subitem_subject_scheme":"Other"},{"subitem_subject":"3D protein structural homology search","subitem_subject_scheme":"Other"},{"subitem_subject":"Triangle ID","subitem_subject_scheme":"Other"},{"subitem_subject":"Neighborhood Triangle ID","subitem_subject_scheme":"Other"},{"subitem_subject":"3D protein structure","subitem_subject_scheme":"Other"},{"subitem_subject":"PDB","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"新規な三角形IDに基づくタンパク質立体構造ホモロジー検索アルゴリズム","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規な三角形IDに基づくタンパク質立体構造ホモロジー検索アルゴリズム","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"1","path":["1222"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-10-09"},"publish_date":"2009-10-09","publish_status":"0","recid":"12551","relation_version_is_last":true,"title":["新規な三角形IDに基づくタンパク質立体構造ホモロジー検索アルゴリズム"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:08:12.347916+00:00"}