@article{oai:soar-ir.repo.nii.ac.jp:00013310,
 author = {Kim,  Kyu-Oh and Akada,  Yaeko and Wei,  Kai and Kim,  Byoung-Suhk and Kim,  Ick-Soo},
 journal = {Journal of Biomaterials and Nanobiotechnology},
 month = {Jul},
 note = {In this work, novel nanostructured core-shell poly (ethylene glycol) (PEG)-polyhedral oligosilsesquioxane (POSS) nanoparticles were used to encapsulate insulin as new drug delivery carriers. The morphologies, particle size and ? potential of th e pure nanostructured core-shell PEG-POSS and th e corresponding insulin-load ed PEG-POSS nanopar-ticles were investigated by transmission electron microscopy (TEM) and laser diffraction particle sizer. TEM analysis demonstrated that pure and insulin-loaded self-assembled PEG-POSS nanoparticles were of spherical shape with core-shell nanostructure, and were well-dispersed and uniform in size distribution. Insulin release test showed that in-sulin was well-protected in side PEG-POSS nanoparticles at gastric pH for 2 hrs, and was released at intestinal pH (pH 6 - 7) where the absorption and activation of the drug are necessary. We therefore believe that such nanostructured PEG-POSS nanoparticles could be useful as a potential carrier for insulin drug delivery systems., Article, Journal of Biomaterials and Nanobiotechnology. 2:201-206 (2011)},
 pages = {201--206},
 title = {Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery},
 volume = {2},
 year = {2011}
}