{"created":"2021-03-01T06:16:14.128002+00:00","id":13310,"links":{},"metadata":{"_buckets":{"deposit":"73baefb1-955d-4139-812d-23440a8cbddb"},"_deposit":{"id":"13310","owners":[],"pid":{"revision_id":0,"type":"depid","value":"13310"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00013310","sets":["1309:1310"]},"author_link":["40324","40325","40326","40327","40328"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-07","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"206","bibliographicPageStart":"201","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"Journal of Biomaterials and Nanobiotechnology"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this work, novel nanostructured core-shell poly (ethylene glycol) (PEG)-polyhedral oligosilsesquioxane (POSS) nanoparticles were used to encapsulate insulin as new drug delivery carriers. The morphologies, particle size and ? potential of th e pure nanostructured core-shell PEG-POSS and th e corresponding insulin-load ed PEG-POSS nanopar-ticles were investigated by transmission electron microscopy (TEM) and laser diffraction particle sizer. TEM analysis demonstrated that pure and insulin-loaded self-assembled PEG-POSS nanoparticles were of spherical shape with core-shell nanostructure, and were well-dispersed and uniform in size distribution. Insulin release test showed that in-sulin was well-protected in side PEG-POSS nanoparticles at gastric pH for 2 hrs, and was released at intestinal pH (pH 6 - 7) where the absorption and activation of the drug are necessary. We therefore believe that such nanostructured PEG-POSS nanoparticles could be useful as a potential carrier for insulin drug delivery systems.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Biomaterials and Nanobiotechnology. 2:201-206 (2011)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Kim, Ick-Soo","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.jNyCjFkV.html"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Scientific Research"}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.4236/jbnb.2011.23025"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.4236/jbnb.2011.23025","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright© 2014 by authors and Scientific Research Publishing Inc."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2158-7027","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kim,  Kyu-Oh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akada,  Yaeko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wei,  Kai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kim,  Byoung-Suhk"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kim,  Ick-Soo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-28"}],"displaytype":"detail","filename":"089_Self-Assembled_Core-Shell_Polye_thylene_glycol-POSS.pdf","filesize":[{"value":"358.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"089_Self-Assembled_Core-Shell_Polye_thylene_glycol-POSS.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/13310/files/089_Self-Assembled_Core-Shell_Polye_thylene_glycol-POSS.pdf"},"version_id":"85bf731f-47e7-4f6b-adc5-488d5b1d5fba"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Self-Assembly","subitem_subject_scheme":"Other"},{"subitem_subject":"Amphiphilic","subitem_subject_scheme":"Other"},{"subitem_subject":"Nanoparticles","subitem_subject_scheme":"Other"},{"subitem_subject":"POSS","subitem_subject_scheme":"Other"},{"subitem_subject":"Insulin","subitem_subject_scheme":"Other"},{"subitem_subject":"Oral Delivery","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["1310"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-08-25"},"publish_date":"2014-08-25","publish_status":"0","recid":"13310","relation_version_is_last":true,"title":["Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:27:33.834627+00:00"}