@article{oai:soar-ir.repo.nii.ac.jp:00013458,
 author = {Yamamoto,  H and kuribayashi,  H and Seshima,  Y and Zhao,  P and Kouno,  I and Taguchi,  G and Shimomura,  K},
 issue = {5},
 journal = {Plant Biotechnology},
 month = {},
 note = {Cultured cells of Sophora flavescens produce (2S)-naringenin-derived prenylated flavanone sophoraflavanone G and liquiritigenin-derived trifolirhizin 6′-O-malonate. The regulation of flavonoid biosynthesis was examined by analyzing the metabolites produced in the cultured cells fed (2RS)-naringenin. The amount of sophoraflavanone G in cells fed 0.1 or 0.3 mM (2RS)-naringenin was two-fold that in control cells, although the conversion ratio was only 5 to 10% of the administered (2S)-naringenin. On the other hand, (2R)-naringenin, which does not occur naturally, was efficiently converted into its 4′,7-di-O-β-D-glucoside. (2S)-Naringenin prenylation activity was higher at the logarithmic growth stage. The cells fed (2RS)-naringenin at a lower concentration (below 0.1 mM), accumulated sophoraflavanone G as the main prenylated flavanone. In contrast, cells fed 0.3 mM (2RS)-naringenin accumulated 8-prenylnaringenin and leachianone G, intermediates of sophoraflavanone G in large amounts. Accumulation of trifolirhizin 6′-O-malonate was suppressed by the addition of naringenin., Article, Plant Biotechnology. 21(5):355-359 (2004)},
 pages = {355--359},
 title = {Metabolism of administered (2RS)-naringenin in flavonoidproducing\ncultured cells of Sophora flavescens},
 volume = {21},
 year = {2004}
}