@techreport{oai:soar-ir.repo.nii.ac.jp:00017065, author = {酒井, 秋男 and 上田, 五雨 and 吉田, 安雄 and 小林, 俊夫 and 久保, 忠嗣}, month = {Mar}, note = {Chronic exposure to high-altutude causes right ventricular hyper -trophy in variety of animal species. We thus investigated the changes of heart weight and cardiac muscle fibers of high-altitude (alt. 2400m) native mice especially when transferred to low-altitude (alt. 650m). In this experiment,t he comparative study of the heart was done among the four groups. The first group was high-altitude native mice (H group,n =5),t he second group (high-altitude native mice) was transferred to low -altitude and reared there for 18 months (HL group,n =4),th e third group was born from high-altitudenative parentsat low-altitude and grown up there (HL-F1group,n=6),the fourth group was low-altitude native mice (L group,n =8). In all cases,th e hearts were removed and separated into two parts of the right (RVW) and the 1eft(LVW) ventricular walls. Then,th e cross sectional area of the ventricular musclefiberswere examined. The results were as follows: (1) The cardiac or right ventricular hypertrophy and thehypertrophyof right ventricular musclefiberswere found in high-altitude native mice. (2) By transferring the high-.altitude native mice to the low-altitude,th e hypertrophied heart,r ight ventricle and right ventricular muscle fibers reached to the low-altitude levels. (3) The low-altitude mice that were born from high-altitude native parents did not show differenceson the heart and right ventricular weight and the cross sectionalareas of right ventricular muscle fibers in comparison with those of low-altitude native mice;, Article, 信州大学環境科学論集7:56-60(1985)}, title = {野生ヒメネズミにおける高地性右心室肥大の低地順応}, year = {1985} }