@techreport{oai:soar-ir.repo.nii.ac.jp:00017090,
 author = {小林,  俊夫 and 矢崎,  久美 and 吉村,  一彦 and 福島,  雅夫 and 久保,  恵嗣 and 半田,  健次郎 and 草間,  昌三 and 酒井,  秋男 and 上田,  五雨},
 month = {Mar},
 note = {We studied the effect of Ca2十antagonistverapamil(V) on right ventricular hypertrophy exposed at high altitude. Male Wistar rats(WR) of an initial weight of 118.2 6.5g(n=48) and spontaneously hypertensive rats(SHR) of initial weight of 83.2士8.0g(n=48) were used. They were divided into four groups. Each group consists of WR(n=12) and SHR(n =12). The first and second groups were taken to a high altitude station(2，400m)，w here they were kept for 60 days. The rats in the first group were given a dietcontaining 125mgjkg of V. The second received no treatment. The rats in the third group treated by Vand in the non-treated fourth group were kept at a laboratory altitude (640m). Mter 60 days of treatment，they were killed，a nd the right ventricular weight(RW) and the weight of the left ventricle plus the septum(LW) were determined. In rats in the first and second groups，ch ronic treatment with V increased RWa nd reduced LW . The ratio of RW to LW in rats with treatment with V were higher values. There was no significant difference in the ratio of RW to LW between WR and SHR in the first and second groups. These findings suggested that the effect of V treatment were not seen on right ventricular hypertrophy of rats exposed at high altitude, Article, 信州大学環境科学論集6:101-103(1984)},
 title = {高血圧自然発症ラット（ＳＨＲ）およびWistar系ラットの長期高地環境暴露による心肥大に対するVerapamilの効果},
 year = {1984}
}