@article{oai:soar-ir.repo.nii.ac.jp:00017201, author = {赤羽, 治郎 and 伊古美, 文雄 and 河野, 元 and 河村, 敏郎 and 丹羽, 源之助}, journal = {信州大學紀要}, month = {Sep}, note = {Many cases of poisoning of nitrolime (one of the most important fertilizers, the chief constituent (f which is calcium cyanamide Ca CN₂) have often occurred among the people engaged in the production. The most noticeable is the fact, that the person inhaled the dust of nitrolime become hypersensitive to ethyl alcohol. We have recently studied experimentally on the symptoms followed the intake of alcohol combined with calcium cyanamide on the human volunteers (our four colleagues). Experiments in these labolatories with calcium cyanamide, showed that subjects who had ingested 0.3g of nitrolime (an otherwise inert dose) developed characteristic symptoms when they subsequently drank a small amount of alcohol (about 60 cc of 20% ethyl alcohol). These symptoms include a feeling of heat in the face, followed by an intense flushing, especially in the face, neck and upper part of the chest. These are followed a little later by palpitations, slight dyspnea, and fall of blood pressure. Nausea and vomiting also developed, and flushing gave away to pallor. These symptoms were accompanied by increasing headache. These unpleasant symptoms disappeared, however, within a few hours, generally leaving the person rather sleepy, and all complaints were almost relieved by a short nap. The sensitizing effect of calcium cyanamide to ethyl alcohol lasted for several days thereafter. These symptoms resembled to those caused by disulfiram (Antabuse) and alcohol closely., Article, 信州大學紀要 (4): 157-165(1953)}, pages = {157--165}, title = {石灰窒素:アルコール併用による急性中毒の実験的研究(人体実験)}, volume = {4}, year = {1953} }