{"created":"2021-03-01T06:20:58.440824+00:00","id":17921,"links":{},"metadata":{"_buckets":{"deposit":"9adb4929-f5a7-4c59-afb2-0953596dc6ae"},"_deposit":{"id":"17921","owners":[],"pid":{"revision_id":0,"type":"depid","value":"17921"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00017921","sets":["1309:1310"]},"author_link":["50044","50045","50046","50047","50048","50049","50050","50051","50052"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-10-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"15566","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"SCIENTIFIC REPORTS"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The insect neuropeptide family FXPRLa, which carries the Phe-Xaa-Pro-Arg-Leu-NH2 sequence at the C-terminus, is involved in many physiological processes. Although ligand–receptor interactions in FXPRLa signaling have been examined using in vitro assays, the correlation between these interactions and in vivo physiological function is unclear. Diapause in the silkworm, Bombyx mori, is thought to be elicited by diapause hormone (DH, an FXPRLa) signaling, which consists of interactions between DH and DH receptor (DHR). Here, we performed transcription activator-like effector nuclease (TALEN)-based mutagenesis of the Bombyx DH-PBAN and DHR genes and isolated the null mutants of these genes in a bivoltine strain. All mutant silkworms were fully viable and showed no abnormalities in the developmental timing of ecdysis or metamorphosis. However, female adults oviposited non-diapause eggs despite diapause-inducing temperature and photoperiod conditions. Therefore, we conclude that DH signaling is essential for diapause induction and consists of highly sensitive and specific interactions between DH and DHR selected during ligand–receptor coevolution in Bombyx mori.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"SCIENTIFIC REPORTS. 5:15566 (2015)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Shiomi, Kunihiro","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.WCnpjFkV.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_text":"Web of Science","subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000363397200001"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"NATURE PUBLISHING GROUP"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"26497859"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=26497859","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1038/srep15566"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/srep15566","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shiomi,  Kunihiro"}],"nameIdentifiers":[{"nameIdentifier":"50044","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takasu,  Yoko"}],"nameIdentifiers":[{"nameIdentifier":"50045","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kunii,  Masayo"}],"nameIdentifiers":[{"nameIdentifier":"50046","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuchiya,  Ryoma"}],"nameIdentifiers":[{"nameIdentifier":"50047","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mukaida,  Moeka"}],"nameIdentifiers":[{"nameIdentifier":"50048","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi,  Masakazu"}],"nameIdentifiers":[{"nameIdentifier":"50049","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sezutsu,  Hideki"}],"nameIdentifiers":[{"nameIdentifier":"50050","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichida, (Takahama), Masatoshi"}],"nameIdentifiers":[{"nameIdentifier":"50051","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizoguchi,  Akira"}],"nameIdentifiers":[{"nameIdentifier":"50052","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-23"}],"displaytype":"detail","filename":"Disruption_of_diapause_induction_by_TALEN-based_gene.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensefree":"This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Disruption_of_diapause_induction_by_TALEN-based_gene.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/17921/files/Disruption_of_diapause_induction_by_TALEN-based_gene.pdf"},"version_id":"70ec5ef4-a29e-4f59-b73f-213156025819"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Disruption of diapause induction by TALEN-based gene mutagenesis in relation to a unique neuropeptide signaling pathway in Bombyx","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Disruption of diapause induction by TALEN-based gene mutagenesis in relation to a unique neuropeptide signaling pathway in Bombyx","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["1310"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-03-23"},"publish_date":"2016-03-23","publish_status":"0","recid":"17921","relation_version_is_last":true,"title":["Disruption of diapause induction by TALEN-based gene mutagenesis in relation to a unique neuropeptide signaling pathway in Bombyx"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:27:27.609543+00:00"}