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Intra-cystic fluid contains abundant amounts of free iron, which causes persistent oxidative stress, a factor that has been suggested to induce malignant transformation. However, the mechanisms linking oxidative stress and carcinogenesis in CCC currently remain unclear. Lipocalin 2 (LCN2), a multifunctional secretory protein, functions as an iron transporter as well as an antioxidant. Therefore, we herein examined the roles of LCN2 in the regulation of intracellular iron concentrations, oxidative stress, DNA damage, and antioxidative functions using LCN2-overexpressing (ES2), and LCN2-silenced (RMG-1) CCC cell lines. The results of calcein staining indicated that the up-regulated expression of LCN2 correlated with increases in intracellular iron concentrations. However, a DCFH-DA assay and 8OHdG staining revealed that LCN2 reduced intracellular levels of reactive oxygen species and DNA damage. Furthermore, the expression of LCN2 suppressed hydrogen peroxide-induced apoptosis and prolonged cell survival, suggesting an antioxidative role for LCN2. The expression of mRNAs and proteins for various oxidative stress-catalyzing enzymes, such as heme oxygenase (HO), superoxide dismutase (SOD), and glutathione peroxidase, was not affected by LCN2, whereas the intracellular concentration of the potent antioxidant, glutathione (GSH), was increased by LCN2. Furthermore, the expression of xCT, a cystine transporter protein, and CD44 variant 8-10 (CD44v), a stem cell marker, was up-regulated by LCN2. Although LCN2 increased intracellular iron concentrations, LCN2-induced GSH may catalyze and override oxidative stress via CD44v and xCT, and subsequently enhance the survival of CCC cells in oxidative stress-rich endometriosis."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "山田, 靖", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "103690", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "12MH043B_shinsa.pdf", "filesize": [{"value": "93.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 93100.0, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/18956/files/12MH043B_shinsa.pdf"}, "version_id": "ef90cb40-2670-4ea9-aa3b-70486ffa7722"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "12MH043B_yoshi.pdf", "filesize": [{"value": "129.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 129000.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/18956/files/12MH043B_yoshi.pdf"}, "version_id": "34a936e0-8a5d-436c-bad3-21577ab76b8c"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-07-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "12MH043B_ronbun.pdf", "filesize": [{"value": "2.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This is an Accepted Manuscript of an article published by Taylor \u0026 Francis in Free Radical Research on 12/02/2016, available online: http://www.tandfonline.com/10.3109/10715762.2015.1134795", "licensetype": "license_note", "mimetype": "application/pdf", "size": 2700000.0, "url": {"label": "博士論文の全文", "objectType": "fulltext", "url": "https://soar-ir.repo.nii.ac.jp/record/18956/files/12MH043B_ronbun.pdf"}, "version_id": "381aabc3-3783-4f53-b4a0-b372fddf4c5c"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant(リポカリン2は変異型CD44の発現亢進を介して卵巣明細胞癌細胞の鉄関連酸化ストレスを減弱し、生存を促進する)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant(リポカリン2は変異型CD44の発現亢進を介して卵巣明細胞癌細胞の鉄関連酸化ストレスを減弱し、生存を促進する)", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["849"], "permalink_uri": "http://hdl.handle.net/10091/00019718", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-06-06"}, "publish_date": "2017-06-06", "publish_status": "0", "recid": "18956", "relation": {}, "relation_version_is_last": true, "title": ["Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant(リポカリン2は変異型CD44の発現亢進を介して卵巣明細胞癌細胞の鉄関連酸化ストレスを減弱し、生存を促進する)"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant(リポカリン2は変異型CD44の発現亢進を介して卵巣明細胞癌細胞の鉄関連酸化ストレスを減弱し、生存を促進する)

http://hdl.handle.net/10091/00019718
http://hdl.handle.net/10091/00019718
4258af2f-3c60-43ec-9ae6-7b82a5563a67
名前 / ファイル ライセンス アクション
12MH043B_shinsa.pdf 内容の要旨 (93.1 kB)
12MH043B_yoshi.pdf 審査結果の要旨 (129.0 kB)
12MH043B_ronbun.pdf 博士論文の全文 (2.7 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2017-06-06
タイトル
言語 en
タイトル Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant(リポカリン2は変異型CD44の発現亢進を介して卵巣明細胞癌細胞の鉄関連酸化ストレスを減弱し、生存を促進する)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 山田, 靖

× 山田, 靖

WEKO 103690

ja 山田, 靖

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 山田 靖. Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant(リポカリン2は変異型CD44の発現亢進を介して卵巣明細胞癌細胞の鉄関連酸化ストレスを減弱し、生存を促進する). 信州大学, 2016, 博士論文.
書誌情報
発行日 2016-03-31
学位授与番号
学位授与番号 13601甲第1059号
学位授与年月日
学位授与年月日 2016-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13601
学位授与機関名 信州大学(Shinshu university)
学位の区分
doctoral
学位の分野
医学
学位の報告番号
甲第1059号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。FREE RADICAL RESEARCH. 50(4):414-425 (2016); doi:10.3109/10715762.2015.1134795.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/26729415/
関連名称 26729415
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.3109/10715762.2015.1134795
関連名称 10.3109/10715762.2015.1134795
権利
権利情報 This is an Accepted Manuscript of an article published by Taylor & Francis in Free Radical Research on 12/02/2016, available online: http://www.tandfonline.com/10.3109/10715762.2015.1134795
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000371933700005
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