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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Novel oestrogen receptor beta-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice

http://hdl.handle.net/10091/00019809
http://hdl.handle.net/10091/00019809
bbffb42d-82ed-46f4-8ed8-eaa71647c747
名前 / ファイル ライセンス アクション
Novel_oestrogen_receptor_beta-selective.pdf Novel_oestrogen_receptor_beta-selective.pdf (1.6 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-08-23
タイトル
言語 en
タイトル Novel oestrogen receptor beta-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Sasayama, Daimei

× Sasayama, Daimei

WEKO 103875

en Sasayama, Daimei

Search repository
Sugiyama, Nobuhiro

× Sugiyama, Nobuhiro

WEKO 103876

en Sugiyama, Nobuhiro

Search repository
Yonekubo, Shigeru

× Yonekubo, Shigeru

WEKO 103877

en Yonekubo, Shigeru

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Pawlak, Akiko

× Pawlak, Akiko

WEKO 103878

en Pawlak, Akiko

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Murasawa, Hiroyasu

× Murasawa, Hiroyasu

WEKO 103879

en Murasawa, Hiroyasu

Search repository
Nakamura, Mie

× Nakamura, Mie

WEKO 103880

en Nakamura, Mie

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Hayashi, Morimichi

× Hayashi, Morimichi

WEKO 103881

en Hayashi, Morimichi

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Ogawa, Takashi

× Ogawa, Takashi

WEKO 103882

en Ogawa, Takashi

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Moro, Makoto

× Moro, Makoto

WEKO 103883

en Moro, Makoto

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Washizuka, Shinsuke

× Washizuka, Shinsuke

WEKO 103884

en Washizuka, Shinsuke

Search repository
Amano, Naoji

× Amano, Naoji

WEKO 103885

en Amano, Naoji

Search repository
Hongo, Kazuhiro

× Hongo, Kazuhiro

WEKO 103886

en Hongo, Kazuhiro

Search repository
Ohnota, Hideki

× Ohnota, Hideki

WEKO 103887

en Ohnota, Hideki

Search repository
信州大学研究者総覧へのリンク
氏名 Sasayama, Daimei
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uNkegpkh.html
信州大学研究者総覧へのリンク
氏名 Sugiyama, Nobuhiro
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.yVAmjNSN.html
信州大学研究者総覧へのリンク
氏名 Washizuka, Shinsuke
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uhnNuakh.html
信州大学研究者総覧へのリンク
氏名 Hongo, Kazuhiro
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jecFHCkh.html
信州大学研究者総覧へのリンク
氏名 Ohnota, Hideki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.yhkmOFyC.html
出版者
出版者 NATURE PUBLISHING GROUP
引用
内容記述タイプ Other
内容記述 SCIENTIFIC REPORTS. 7:4663 (2017)
書誌情報 SCIENTIFIC REPORTS

巻 7, p. 4663, 発行日 2017-07-05
抄録
内容記述タイプ Abstract
内容記述 Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity and depressive symptoms. To delineate potential effects of ER beta activation in postmenopausal women, we investigated the effects of a novel oestrogen receptor beta-selective ligand (C-1) in ovariectomized mice. Uterine weight, depressive behaviour, and weight gain were examined in sham-operated control mice and ovariectomized mice administered placebo, C-1, or 17 beta-oestradiol (E2). Administration of C-1 or E2 reduced body weight gain and depressive-like behaviour in ovariectomized mice, as assessed by the forced swim test. In addition, administration of E2 to ovariectomized mice increased uterine weight, but administration of C-1 did not result in a significant increase in uterine weight. These results suggest that the selective activation of ERa in ovariectomized mice may have protective effects against obesity and depressive-like behaviour without causing an increase in uterine weight. The present findings raise the possibility of the application of ER beta-ligands such as C-1 as a novel treatment for obesity and depression in postmenopausal women.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 2045-2322
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/28680060
関連名称 28680060
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41598-017-04946-5
関連名称 10.1038/s41598-017-04946-5
権利
権利情報 Copyright © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this<br/>article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000404846300001
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