{"_buckets": {"deposit": "b98b809f-488e-4151-b1d9-d8feb37f7552"}, "_deposit": {"id": "19047", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19047"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00019047", "sets": ["462"]}, "author_link": ["103875", "103876", "103877", "103878", "103879", "103880", "103881", "103882", "103883", "103884", "103885", "103886", "103887"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-07-05", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "4663", "bibliographicVolumeNumber": "7", "bibliographic_titles": [{"bibliographic_title": "SCIENTIFIC REPORTS"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity and depressive symptoms. To delineate potential effects of ER beta activation in postmenopausal women, we investigated the effects of a novel oestrogen receptor beta-selective ligand (C-1) in ovariectomized mice. Uterine weight, depressive behaviour, and weight gain were examined in sham-operated control mice and ovariectomized mice administered placebo, C-1, or 17 beta-oestradiol (E2). Administration of C-1 or E2 reduced body weight gain and depressive-like behaviour in ovariectomized mice, as assessed by the forced swim test. In addition, administration of E2 to ovariectomized mice increased uterine weight, but administration of C-1 did not result in a significant increase in uterine weight. These results suggest that the selective activation of ERa in ovariectomized mice may have protective effects against obesity and depressive-like behaviour without causing an increase in uterine weight. The present findings raise the possibility of the application of ER beta-ligands such as C-1 as a novel treatment for obesity and depression in postmenopausal women.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "SCIENTIFIC REPORTS. 7:4663 (2017)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Sasayama, Daimei", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.uNkegpkh.html"}, {"subitem_link_text": "Sugiyama, Nobuhiro", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.yVAmjNSN.html"}, {"subitem_link_text": "Washizuka, Shinsuke", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.uhnNuakh.html"}, {"subitem_link_text": "Hongo, Kazuhiro", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.jecFHCkh.html"}, {"subitem_link_text": "Ohnota, Hideki", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.yhkmOFyC.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000404846300001"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "NATURE PUBLISHING GROUP"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "28680060"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/28680060", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1038/s41598-017-04946-5"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1038/s41598-017-04946-5", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this\u003cbr/\u003earticle are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. "}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2045-2322", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2045-2322", "subitem_source_identifier_type": "PISSN"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "FORCED SWIM TEST; POSTMENOPAUSAL WOMEN; CELL-PROLIFERATION; ESTRADIOL; EXPRESSION; RALOXIFENE; STRESS; MODEL; PROGESTERONE; METAANALYSIS"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity and depressive symptoms. To delineate potential effects of ER beta activation in postmenopausal women, we investigated the effects of a novel oestrogen receptor beta-selective ligand (C-1) in ovariectomized mice. Uterine weight, depressive behaviour, and weight gain were examined in sham-operated control mice and ovariectomized mice administered placebo, C-1, or 17 beta-oestradiol (E2). Administration of C-1 or E2 reduced body weight gain and depressive-like behaviour in ovariectomized mice, as assessed by the forced swim test. In addition, administration of E2 to ovariectomized mice increased uterine weight, but administration of C-1 did not result in a significant increase in uterine weight. These results suggest that the selective activation of ERa in ovariectomized mice may have protective effects against obesity and depressive-like behaviour without causing an increase in uterine weight. The present findings raise the possibility of the application of ER beta-ligands such as C-1 as a novel treatment for obesity and depression in postmenopausal women."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sasayama, Daimei", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "103875", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugiyama, Nobuhiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "103876", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yonekubo, Shigeru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "103877", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Pawlak, Akiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "103878", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murasawa, Hiroyasu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "103879", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Mie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "103880", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, Morimichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "103881", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ogawa, Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "103882", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Moro, Makoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "103883", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Washizuka, Shinsuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "103884", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Amano, Naoji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "103885", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hongo, Kazuhiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "103886", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohnota, Hideki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "103887", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-08-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Novel_oestrogen_receptor_beta-selective.pdf", "filesize": [{"value": "1.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Copyright © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this\u003cbr/\u003earticle are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.", "licensetype": "license_note", "mimetype": "application/pdf", "size": 1600000.0, "url": {"label": "Novel_oestrogen_receptor_beta-selective.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/19047/files/Novel_oestrogen_receptor_beta-selective.pdf"}, "version_id": "3b851f39-da69-484f-87be-b0cf644854a5"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Novel oestrogen receptor beta-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Novel oestrogen receptor beta-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/00019809", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-08-23"}, "publish_date": "2017-08-23", "publish_status": "0", "recid": "19047", "relation": {}, "relation_version_is_last": true, "title": ["Novel oestrogen receptor beta-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice"], "weko_shared_id": -1}