{"_buckets": {"deposit": "b98b809f-488e-4151-b1d9-d8feb37f7552"}, "_deposit": {"id": "19047", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19047"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00019047"}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-07-05", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "4663", "bibliographicVolumeNumber": "7", "bibliographic_titles": [{"bibliographic_title": "SCIENTIFIC REPORTS"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity and depressive symptoms. To delineate potential effects of ER beta activation in postmenopausal women, we investigated the effects of a novel oestrogen receptor beta-selective ligand (C-1) in ovariectomized mice. Uterine weight, depressive behaviour, and weight gain were examined in sham-operated control mice and ovariectomized mice administered placebo, C-1, or 17 beta-oestradiol (E2). Administration of C-1 or E2 reduced body weight gain and depressive-like behaviour in ovariectomized mice, as assessed by the forced swim test. In addition, administration of E2 to ovariectomized mice increased uterine weight, but administration of C-1 did not result in a significant increase in uterine weight. These results suggest that the selective activation of ERa in ovariectomized mice may have protective effects against obesity and depressive-like behaviour without causing an increase in uterine weight. 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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this\narticle are included in the article\u2019s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article\u2019s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. 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Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity and depressive symptoms. To delineate potential effects of ER beta activation in postmenopausal women, we investigated the effects of a novel oestrogen receptor beta-selective ligand (C-1) in ovariectomized mice. Uterine weight, depressive behaviour, and weight gain were examined in sham-operated control mice and ovariectomized mice administered placebo, C-1, or 17 beta-oestradiol (E2). Administration of C-1 or E2 reduced body weight gain and depressive-like behaviour in ovariectomized mice, as assessed by the forced swim test. In addition, administration of E2 to ovariectomized mice increased uterine weight, but administration of C-1 did not result in a significant increase in uterine weight. These results suggest that the selective activation of ERa in ovariectomized mice may have protective effects against obesity and depressive-like behaviour without causing an increase in uterine weight. The present findings raise the possibility of the application of ER beta-ligands such as C-1 as a novel treatment for obesity and depression in postmenopausal women."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sasayama, Daimei"}], "nameIdentifiers": [{"nameIdentifier": "103875", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugiyama, Nobuhiro"}], "nameIdentifiers": [{"nameIdentifier": "103876", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yonekubo, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "103877", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Pawlak, Akiko"}], "nameIdentifiers": [{"nameIdentifier": "103878", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murasawa, Hiroyasu"}], "nameIdentifiers": [{"nameIdentifier": "103879", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Mie"}], "nameIdentifiers": [{"nameIdentifier": "103880", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, Morimichi"}], "nameIdentifiers": [{"nameIdentifier": "103881", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ogawa, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "103882", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Moro, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "103883", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Washizuka, Shinsuke"}], "nameIdentifiers": [{"nameIdentifier": "103884", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Amano, Naoji"}], "nameIdentifiers": [{"nameIdentifier": "103885", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hongo, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "103886", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohnota, Hideki"}], "nameIdentifiers": [{"nameIdentifier": "103887", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-08-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Novel_oestrogen_receptor_beta-selective.pdf", "filesize": [{"value": "1.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Copyright \u00a9 The Author(s) 2017. 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