@article{oai:soar-ir.repo.nii.ac.jp:00019047, author = {Sasayama, Daimei and Sugiyama, Nobuhiro and Yonekubo, Shigeru and Pawlak, Akiko and Murasawa, Hiroyasu and Nakamura, Mie and Hayashi, Morimichi and Ogawa, Takashi and Moro, Makoto and Washizuka, Shinsuke and Amano, Naoji and Hongo, Kazuhiro and Ohnota, Hideki}, journal = {SCIENTIFIC REPORTS}, month = {Jul}, note = {Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity and depressive symptoms. To delineate potential effects of ER beta activation in postmenopausal women, we investigated the effects of a novel oestrogen receptor beta-selective ligand (C-1) in ovariectomized mice. Uterine weight, depressive behaviour, and weight gain were examined in sham-operated control mice and ovariectomized mice administered placebo, C-1, or 17 beta-oestradiol (E2). Administration of C-1 or E2 reduced body weight gain and depressive-like behaviour in ovariectomized mice, as assessed by the forced swim test. In addition, administration of E2 to ovariectomized mice increased uterine weight, but administration of C-1 did not result in a significant increase in uterine weight. These results suggest that the selective activation of ERa in ovariectomized mice may have protective effects against obesity and depressive-like behaviour without causing an increase in uterine weight. The present findings raise the possibility of the application of ER beta-ligands such as C-1 as a novel treatment for obesity and depression in postmenopausal women., Article, SCIENTIFIC REPORTS. 7:4663 (2017)}, title = {Novel oestrogen receptor beta-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice}, volume = {7}, year = {2017} }