@article{oai:soar-ir.repo.nii.ac.jp:00019061, author = {Nakayama, Jun}, issue = {1}, journal = {ACTA HISTOCHEMICA ET CYTOCHEMICA}, month = {}, note = {Gastric gland mucin is secreted from gland mucous cells, including pyloric gland cells and mucous neck cells located in the lower layer of the gastric mucosa. These mucins typically contain O-glycans carrying terminal alpha 1,4-linked N-acetylglucosamine residues (alpha GlcNAc) attached to the scaffold protein MUC6, and biosynthesis of the O-glycans is catalyzed by the glycosyltransferase, alpha 1,4-N-acetylglucosaminyltransferase (alpha 4GnT). We previously used expression cloning to isolate cDNA encoding alpha 4GnT, and then demonstrated that aGlcNAc functions as natural antibiotic against Helicobacter pylori, a microbe causing various gastric diseases including gastric cancer. More recently, it was shown that aGlcNAc serves as a tumor suppressor for differentiated-type adenocarcinoma. This review summarizes these findings and identifies dual roles for aGlcNAc in gastric cancer., Article, ACTA HISTOCHEMICA ET CYTOCHEMICA. 47(1):1-9 (2014)}, pages = {1--9}, title = {Dual Roles of Gastric Gland Mucin-specific O-glycans in Prevention of Gastric Cancer}, volume = {47}, year = {2014} }