{"created":"2021-03-01T06:22:08.149428+00:00","id":19061,"links":{},"metadata":{"_buckets":{"deposit":"bac536fa-ae00-47ad-bc6b-d532f54d18aa"},"_deposit":{"id":"19061","owners":[],"pid":{"revision_id":0,"type":"depid","value":"19061"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00019061","sets":["461:462"]},"author_link":["103922"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"9","bibliographicPageStart":"1","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"ACTA HISTOCHEMICA ET CYTOCHEMICA"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Gastric gland mucin is secreted from gland mucous cells, including pyloric gland cells and mucous neck cells located in the lower layer of the gastric mucosa. These mucins typically contain O-glycans carrying terminal alpha 1,4-linked N-acetylglucosamine residues (alpha GlcNAc) attached to the scaffold protein MUC6, and biosynthesis of the O-glycans is catalyzed by the glycosyltransferase, alpha 1,4-N-acetylglucosaminyltransferase (alpha 4GnT). We previously used expression cloning to isolate cDNA encoding alpha 4GnT, and then demonstrated that aGlcNAc functions as natural antibiotic against Helicobacter pylori, a microbe causing various gastric diseases including gastric cancer. More recently, it was shown that aGlcNAc serves as a tumor suppressor for differentiated-type adenocarcinoma. This review summarizes these findings and identifies dual roles for aGlcNAc in gastric cancer.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"ACTA HISTOCHEMICA ET CYTOCHEMICA. 47(1):1-9 (2014)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Nakayama, Jun","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000342658500001"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"JAPAN SOC HISTOCHEMISTRY & CYTOCHEMISTRY"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"24761044"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/24761044","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1267/ahc.13034"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1267/ahc.13034","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2014 The Japan Society of Histochemistry and Cytochemistry"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0044-5991","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508022","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakayama, Jun","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-20"}],"displaytype":"detail","filename":"Dual_Roles_of_Gastric_Gland_Mucin-specific_O-glycans.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensefree":"© 2014 The Japan Society of Histochemistry and Cytochemistry","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Dual_Roles_of_Gastric_Gland_Mucin-specific_O-glycans.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/19061/files/Dual_Roles_of_Gastric_Gland_Mucin-specific_O-glycans.pdf"},"version_id":"e490263e-784e-4679-bbf6-a114179cbd0e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"expression cloning","subitem_subject_scheme":"Other"},{"subitem_subject":"glycosyltransferase","subitem_subject_scheme":"Other"},{"subitem_subject":"H. pylori","subitem_subject_scheme":"Other"},{"subitem_subject":"knockout mouse","subitem_subject_scheme":"Other"},{"subitem_subject":"mucin histochemistry","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dual Roles of Gastric Gland Mucin-specific O-glycans in Prevention of Gastric Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dual Roles of Gastric Gland Mucin-specific O-glycans in Prevention of Gastric Cancer","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-09-20"},"publish_date":"2017-09-20","publish_status":"0","recid":"19061","relation_version_is_last":true,"title":["Dual Roles of Gastric Gland Mucin-specific O-glycans in Prevention of Gastric Cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T03:55:35.370910+00:00"}