{"created":"2021-03-01T06:22:08.525671+00:00","id":19067,"links":{},"metadata":{"_buckets":{"deposit":"e229d9df-a5cb-4fd4-992e-e4755b889439"},"_deposit":{"id":"19067","owners":[],"pid":{"revision_id":0,"type":"depid","value":"19067"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00019067","sets":["461:462"]},"author_link":["104011","104012","104013","104014","104015","104016","104017","104018","104019","104020"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-09-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageStart":"e107003","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"PLOS ONE"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: Importance of fatty acid components and imbalances has emerged in coronary heart disease. In this study, we analyzed fatty acids and ankle-brachial index (ABI) in a Japanese cohort. Methods: Peripheral arterial disease (PAD) was diagnosed in 101 patients by ABI <= 0.90 and/or by angiography. Traditional cardiovascular risk factors and components of serum fatty acids were examined in all patients (mean age 73.2 +/- 0.9 years; 81 males), and compared with those in 373 age- and sex-matched control subjects with no evidence of PAD. Results: The presence of PAD (mean ABI: 0.71 +/- 0.02) was independently associated with low levels of gamma-linolenic acid (GLA) (OR: 0.90; 95% CI: 0.85-0.96; P = 0.002), eicosapentaenoic acid: arachidonic acid (EPA: AA) ratio (OR: 0.38; 95% CI: 0.17-0.86; P = 0.021), and estimated glomerular filtration rate (OR: 0.97; 95% CI: 0.96-0.98; P<0.0001), and with a high hemoglobin A1c level (OR: 1.34; 95% CI: 1.06-1.69; P = 0.013). Individuals with lower levels of GLA (<= 7.95 mu g/mL) and a lower EPA: AA ratio (<= 0.55) had the lowest ABI (0.96 +/- 0.02, N = 90), while the highest ABI (1.12 +/- 0.01, N = 78) was observed in individuals with higher values of both GLA and EPA: AA ratio (P<0.0001). Conclusion: A low level of GLA and a low EPA: AA ratio are independently associated with the presence of PAD. Specific fatty acid abnormalities and imbalances could lead to new strategies for risk stratification and prevention in PAD patients.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PLOS ONE. 9(9):e107003 (2014)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Izawa, Atsushi","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.yNnVgpkh.html"},{"subitem_link_text":"Shiba, Yuji","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.ZCnmumkh.html"},{"subitem_link_text":"Motoki, Hirohiko","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.ymfFgpkh.html"},{"subitem_link_text":"Okada, Ayako","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.ZUnNPUym.html"},{"subitem_link_text":"Miyashita, Yusuke","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.yUfmgpkh.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000347993600086"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PUBLIC LIBRARY SCIENCE"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"25191963"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/25191963","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1371/journal.pone.0107003"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0107003","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2014 Gautam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Gautam, Milan","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Izawa, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiba, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Motoki, Hirohiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeuchi, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okada, Ayako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyashita, Yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koyama, Jun","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Uichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-20"}],"displaytype":"detail","filename":"Importance_Fatty_Acid_Compositions_Patients.pdf","filesize":[{"value":"361.2 kB"}],"format":"application/pdf","licensefree":"Copyright © 2014 Gautam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Importance_Fatty_Acid_Compositions_Patients.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/19067/files/Importance_Fatty_Acid_Compositions_Patients.pdf"},"version_id":"98de314b-b1df-4e8f-bd5c-53319aa176f5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Importance of Fatty Acid Compositions in Patients with Peripheral Arterial Disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Importance of Fatty Acid Compositions in Patients with Peripheral Arterial Disease","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-09-20"},"publish_date":"2017-09-20","publish_status":"0","recid":"19067","relation_version_is_last":true,"title":["Importance of Fatty Acid Compositions in Patients with Peripheral Arterial Disease"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:40:03.911873+00:00"}