{"_buckets": {"deposit": "3fef24c1-6e20-46f1-96ac-20bf5e2875df"}, "_deposit": {"id": "19068", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19068"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00019068", "sets": ["462"]}, "author_link": ["104021", "104022", "104023", "104024", "104025", "104026", "104027", "104028", "104029", "104030"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "1981", "bibliographicPageStart": "1975", "bibliographicVolumeNumber": "189", "bibliographic_titles": [{"bibliographic_title": "JOURNAL OF UROLOGY"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Purpose: We studied whether cold stress induced detrusor overactivity in ovariectomized rats is associated with increased thermosensitive TRPM8 channel expression in the skin and whether the response could be inhibited by alpha 1-adrenergic receptor blockade. Materials and Methods: A total of 24 Sprague-Dawley (R) rats at postnatal week 30 were randomly selected for ovariectomy (16) or sham ovariectomy (8). Five weeks later cystometric measurements of conscious, freely moving rats were made at room temperature (mean +/- SEM 28C +/- 2C) for 20 minutes. Eight ovariectomized rats were intravenously administered 1.0 mg/kg naftopidil. The other 8 ovariectomized and 8 sham operated rats were given naftopidil-free vehicle. Five minutes later they were transferred to a low temperature environment (mean 4C +/- 2C) and micturition patterns were again recorded. TRPM8 channel expression in lumbar skin was estimated by real-time reverse-transcriptase polymerase chain reaction and immunohistochemistry. Results: TRPM8 channel mRNA and protein in the skin of ovariectomized rats were significantly higher than in sham operated rats. At room temperature micturition parameters were similar in sham operated and ovariectomized rats. At low temperature sham operated and ovariectomized rats showed cold stress induced detrusor overactivity but increased micturition frequency and decreased bladder capacity were significantly greater in ovariectomized rats. Treatment of ovariectomized rats with naftopidil inhibited cold stress induced detrusor overactivity. Conclusions: Cold stress induced detrusor overactivity in rats with decreased estrogen is associated with TRPM8 channel up-regulation in the skin and mediated by nerve pathways using alpha 1-adrenergic receptors.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "JOURNAL OF UROLOGY. 189(5):1975-1981 (2013)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Ishizuka, Osamu", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.gmfaHekh.html"}, {"subitem_link_text": "Imamura, Tetsuya", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.ypACOmyC.html"}, {"subitem_link_text": "Nishizawa, Osamu", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000319262900113"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "ELSEVIER SCIENCE INC"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "23069383"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/23069383", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.juro.2012.10.014"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.juro.2012.10.014", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0022-5347", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0022-5347", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00708666", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "urinary bladder; estrogens; cold temperature; TRPM8 protein, human; lower urinary tract symptoms"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "LOWER URINARY-TRACT; CONSCIOUS RATS; SKIN; ESTROGENS; BLADDER; SYMPTOMS; AFFINITY; MENTHOL; NEURONS; BETA"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Purpose: We studied whether cold stress induced detrusor overactivity in ovariectomized rats is associated with increased thermosensitive TRPM8 channel expression in the skin and whether the response could be inhibited by alpha 1-adrenergic receptor blockade. Materials and Methods: A total of 24 Sprague-Dawley (R) rats at postnatal week 30 were randomly selected for ovariectomy (16) or sham ovariectomy (8). Five weeks later cystometric measurements of conscious, freely moving rats were made at room temperature (mean +/- SEM 28C +/- 2C) for 20 minutes. Eight ovariectomized rats were intravenously administered 1.0 mg/kg naftopidil. The other 8 ovariectomized and 8 sham operated rats were given naftopidil-free vehicle. Five minutes later they were transferred to a low temperature environment (mean 4C +/- 2C) and micturition patterns were again recorded. TRPM8 channel expression in lumbar skin was estimated by real-time reverse-transcriptase polymerase chain reaction and immunohistochemistry. Results: TRPM8 channel mRNA and protein in the skin of ovariectomized rats were significantly higher than in sham operated rats. At room temperature micturition parameters were similar in sham operated and ovariectomized rats. At low temperature sham operated and ovariectomized rats showed cold stress induced detrusor overactivity but increased micturition frequency and decreased bladder capacity were significantly greater in ovariectomized rats. Treatment of ovariectomized rats with naftopidil inhibited cold stress induced detrusor overactivity. Conclusions: Cold stress induced detrusor overactivity in rats with decreased estrogen is associated with TRPM8 channel up-regulation in the skin and mediated by nerve pathways using alpha 1-adrenergic receptors."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Noguchi, Wataru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104021", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishizuka, Osamu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104022", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imamura, Tetsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104023", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kurizaki, Yoshiki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104024", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamagishi, Takahiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104025", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yokoyama, Hitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104026", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lei, Zhang", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104027", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Silwal, Sudha Gautam", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104028", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishizawa, Osamu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104029", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Andersson, Karl-Erik", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104030", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-09-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "The_Relationship_Between_alpha_1-Adrenergic_Receptors_TRPM8_Channels.pdf", "filesize": [{"value": "517.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "© 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/", "licensetype": "license_note", "mimetype": "application/pdf", "size": 517299.99999999994, "url": {"label": "The_Relationship_Between_alpha_1-Adrenergic_Receptors_TRPM8_Channels.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/19068/files/The_Relationship_Between_alpha_1-Adrenergic_Receptors_TRPM8_Channels.pdf"}, "version_id": "179aa4b6-de69-4c1a-a277-6806d20dedb5"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "urinary bladder", "subitem_subject_scheme": "Other"}, {"subitem_subject": "estrogens", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cold temperature", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TRPM8 protein, human", "subitem_subject_scheme": "Other"}, {"subitem_subject": "lower urinary tract symptoms", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The Relationship Between alpha 1-Adrenergic Receptors and TRPM8 Channels in Detrusor Overactivity Induced by Cold Stress in Ovariectomized Rats", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The Relationship Between alpha 1-Adrenergic Receptors and TRPM8 Channels in Detrusor Overactivity Induced by Cold Stress in Ovariectomized Rats", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/00019830", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-09-20"}, "publish_date": "2017-09-20", "publish_status": "0", "recid": "19068", "relation": {}, "relation_version_is_last": true, "title": ["The Relationship Between alpha 1-Adrenergic Receptors and TRPM8 Channels in Detrusor Overactivity Induced by Cold Stress in Ovariectomized Rats"], "weko_shared_id": -1}