{"created":"2021-03-01T06:22:26.045974+00:00","id":19351,"links":{},"metadata":{"_buckets":{"deposit":"03009f2e-99e6-4be0-a8a1-511e47d07199"},"_deposit":{"id":"19351","owners":[],"pid":{"revision_id":0,"type":"depid","value":"19351"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00019351","sets":["461:462"]},"author_link":["104611","104612","104613","104614","104615","104616","104617","104618"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"357","bibliographicPageStart":"347","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"CURRENT PROTEIN & PEPTIDE SCIENCE"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adrenomedullin (ADM), originally identified as a vasodilating peptide, is now recognized to be a pleiotropic molecule involved in both the pathogenesis of cardiovascular diseases and circulatory homeostasis. Homozygotes of ADM knockout mice (ADM-/-) were lethal at mid-gestation with abnormalities of vascular development and this finding clarified the angiogenic potency of ADM. Calcitonin gene-related peptide (CGRP), which has a structure and function similar to that of ADM, has been identified as a family peptide of ADM. Unlike ADM-/-, CGRP-/- were apparently normal. Therefore, the study of knockout mice first clarified the distinctly different physiological roles between ADM and CGRP. In contrast, heterozygotes of ADM knockout mice (ADM+/-) were alive but showed blood pressure elevation, reduced neovascularization, and enhanced neointimal formation by arterial injury. Based on these observations, there was hope ADM would have a therapeutic use. However, ADM has a short half-life in the blood stream and its application in chronic disease has limitations. Therefore, we focused on the ADM receptor system. The calcitonin-receptor-like receptor (CLR), which is the ADM receptor, associates with one of the accessory proteins, called receptor activity-modifying proteins (RAMPs). By interacting with RAMP1, CLR exhibits a high affinity for CGRP, whereas by interacting with either RAMP2 or -3, CLR exhibits a high affinity for ADM. We generated RAMP knockout mice and found that vascular phenotypes similar to ADM-/- were reproduced only in RAMP2-/-. This shows that RAMP2 is the key determinant of the vascular functions of ADM. RAMP2 could be an attractive therapeutic target in cardiovascular diseases.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"CURRENT PROTEIN & PEPTIDE SCIENCE. 14(5):347-357 (2013)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Shindo, Takayuki","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.OCLpOayV.html"},{"subitem_link_text":"Sakurai, Takayuki","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.jaLUuNkh.html"},{"subitem_link_text":"Kamiyoshi, Akiko","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.OpLVuNkh.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_text":"Web of Science","subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000324167600001"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BENTHAM SCIENCE PUBL LTD"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"23745699"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/23745699","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.2174/13892037113149990052"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2174/13892037113149990052","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 Bentham Science Publishers"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1389-2037","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11692455","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shindo, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"104611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakurai, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"104612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamiyoshi, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"104613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichikawa-Shindo, Yuka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"104614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimoyama, Natsumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"104615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iinuma, Nobuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"104616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arai, Takuma","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"104617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyagawa, Shinichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"104618","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-28"}],"displaytype":"detail","filename":"Regulation_ Adrenomedullin_its_Family_Peptide_RAMP_System.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensefree":"© 2013 Bentham Science Publishers","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Regulation_ Adrenomedullin_its_Family_Peptide_RAMP_System.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/19351/files/Regulation_ Adrenomedullin_its_Family_Peptide_RAMP_System.pdf"},"version_id":"15eb7fbe-a35f-4ae3-9547-0ebe445bc36a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adrenomedullin","subitem_subject_scheme":"Other"},{"subitem_subject":"receptor activity-modifying proteins","subitem_subject_scheme":"Other"},{"subitem_subject":"knockout mouse","subitem_subject_scheme":"Other"},{"subitem_subject":"angiogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"lymphangiogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelial cell","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regulation of Adrenomedullin and its Family Peptide by RAMP System - Lessons from Genetically Engineered Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulation of Adrenomedullin and its Family Peptide by RAMP System - Lessons from Genetically Engineered Mice","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-12-28"},"publish_date":"2017-12-28","publish_status":"0","recid":"19351","relation_version_is_last":true,"title":["Regulation of Adrenomedullin and its Family Peptide by RAMP System - Lessons from Genetically Engineered Mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:15:23.817679+00:00"}