{"_buckets": {"deposit": "1f6405d7-87e7-4789-8ab2-aafefff997ed"}, "_deposit": {"id": "19990", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19990"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00019990", "sets": ["1016:1017"]}, "author_link": ["105953"], "item_1628147817048": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "102", "bibliographicPageStart": "73", "bibliographicVolumeNumber": "159", "bibliographic_titles": [{"bibliographic_title": "AMINO ACID FERMENTATION"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Lysine fermentation by Corynebacterium glutamicum was developed in 1958 by Kyowa Hakko Kogyo Co. Ltd. (current Kyowa Hakko Bio Co. Ltd.) and is the second oldest amino acid fermentation process after glutamate fermentation. The fundamental mechanism of lysine production, discovered in the early stages of the process\u0027s history, gave birth to the concept known as \"metabolic regulatory fermentation,\"which is now widely applied to metabolite production. After the development of rational metabolic engineering, research on lysine production first highlighted the need for engineering of the central metabolism from the viewpoints of precursor supply and NADPH regeneration. Furthermore, the existence of active export systems for amino acids was first demonstrated for lysine in C. glutamicum, and this discovery has resulted in the current recognition of such exporters as an important consideration in metabolite production. Lysine fermentation is also notable as the first process to which genomics was successfully applied to improve amino acid production. 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