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  1. 070 農学部, 大学院農学研究科
  2. 0701 学術論文

Lysine Fermentation: History and Genome Breeding

http://hdl.handle.net/10091/00020751
49cb329a-05dc-47a1-9641-24663bd95bf4
名前 / ファイル ライセンス アクション
Lysine_Fermentation_History_and_Genome_Breeding.pdf Lysine_Fermentation_History_and_Genome_Breeding.pdf (610.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-07-24
タイトル
言語 en
タイトル Lysine Fermentation: History and Genome Breeding
言語
言語 eng
キーワード
主題Scheme Other
主題 Corynebacterium glutamicum
キーワード
主題Scheme Other
主題 Downstream processing
キーワード
主題Scheme Other
主題 Escherichia coli
キーワード
主題Scheme Other
主題 Genome breeding
キーワード
主題Scheme Other
主題 Lysine market
キーワード
主題Scheme Other
主題 Lysine-producing strains
キーワード
主題Scheme Other
主題 Lysine production technology
キーワード
主題Scheme Other
主題 Product forms
キーワード
主題Scheme Other
主題 Systems metabolic engineering
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Ikeda, Masato

× Ikeda, Masato

WEKO 105953

Ikeda, Masato

Search repository
信州大学研究者総覧へのリンク
氏名 Ikeda, Masato
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uhLNPUkh.html
出版者
出版者 SPRINGER JAPAN
引用
内容記述タイプ Other
内容記述 In: Yokota A., Ikeda M. (eds) Amino Acid Fermentation. Advances in Biochemical Engineering/Biotechnology, 159:73-102 (2017)
書誌情報 AMINO ACID FERMENTATION

巻 159, p. 73-102, 発行日 2017
抄録
内容記述タイプ Abstract
内容記述 Lysine fermentation by Corynebacterium glutamicum was developed in 1958 by Kyowa Hakko Kogyo Co. Ltd. (current Kyowa Hakko Bio Co. Ltd.) and is the second oldest amino acid fermentation process after glutamate fermentation. The fundamental mechanism of lysine production, discovered in the early stages of the process's history, gave birth to the concept known as "metabolic regulatory fermentation,"which is now widely applied to metabolite production. After the development of rational metabolic engineering, research on lysine production first highlighted the need for engineering of the central metabolism from the viewpoints of precursor supply and NADPH regeneration. Furthermore, the existence of active export systems for amino acids was first demonstrated for lysine in C. glutamicum, and this discovery has resulted in the current recognition of such exporters as an important consideration in metabolite production. Lysine fermentation is also notable as the first process to which genomics was successfully applied to improve amino acid production. The first global "genome breeding" strategy was developed using a lysine producer as a model; this has since led to new lysine producers that are more efficient than classical industrial producers. These advances in strain development technology, combined with recent systems-level approaches, have almost achieved the optimization of entire cellular systems as cell factories for lysine production. In parallel, the continuous improvement of the process has resulted not only in fermentation processes with reduced load on downstream processing but also in commercialization of various product forms according to their intended uses. Nowadays lysine fermentation underpins a giant lysine demand of more than 2 million metric tons per year.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISBN
関連識別子
識別子タイプ ISBN
関連識別子 978-4-431-56518-5
ISSN
収録物識別子タイプ ISSN
収録物識別子 0724-6145
書誌レコードID
関連識別子
識別子タイプ NCID
関連識別子 BB23761867
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/10_2016_27
関連名称
関連名称 10.1007/10_2016_27
権利
権利情報 Copyright © Springer International Publishing Switzerland 2016
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000414557600006
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