{"created":"2022-12-01T04:09:02.448740+00:00","id":2001244,"links":{},"metadata":{"_buckets":{"deposit":"5a9cf565-0fcc-49a4-a58f-50a447183e51"},"_deposit":{"id":"2001244","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2001244"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:02001244","sets":["461:462"]},"author_link":[],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-11-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1069","bibliographicPageStart":"1057","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"JACC. Basic to translational science"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The treatment of pediatric heart failure is a long-standing unmet medical need. Angiotensin II supports mammalian perinatal circulation by activating cardiac L-type Ca2+ channels through angiotensin type 1 receptor (AT1R) and β-arrestin. TRV027, a β-arrestin-biased AT1R agonist, that has been reported to be safe but not effective for adult patients with heart failure, activates the AT1R/β-arrestin pathway. We found that TRV027 evokes a long-acting positive inotropic effect specifically on immature cardiac myocytes through the AT1R/β-arrestin/L-type Ca2+ channel pathway with minimum effect on heart rate, oxygen consumption, reactive oxygen species production, and aldosterone secretion. Thus, TRV027 could be utilized as a valuable drug specific for pediatric heart failure.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"JACC. Basic to translational science 5(11) : 1057-1069(2020)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"川岸, 裕幸","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.Zefaumkh.html"},{"subitem_link_text":"中田, 勉","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.OVkhuNkh.html"},{"subitem_link_text":"冨田, 拓郎","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.OpTCumDV.html"},{"subitem_link_text":"門田, 真","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.OaSaPNym.html"},{"subitem_link_text":"山田, 充彦","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.jhSCupca.html"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"33294739"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/33294739/","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1016/j.jacbts.2020.08.011"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jacbts.2020.08.011","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2452-302X","subitem_source_identifier_type":"EISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kashihara, Toshihide","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kawagishi, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakada, Tsutomu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Numaga-Tomita, Takuro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kadota, Shin","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Wolf, Elena E.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Du, Cheng-Kun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shiba, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Morimoto, Sachio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamada, Mitsuhiko","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-01"}],"filename":"18K06870_1.pdf","format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18K06870_1.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/2001244/files/18K06870_1.pdf"},"version_id":"c21e57ff-4c7b-46d5-afb1-647a30078d61"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"β-arrestin–biased AT1 angiotensin receptor agonist","subitem_subject_scheme":"Other"},{"subitem_subject":"congenital dilated cardiomyopathy","subitem_subject_scheme":"Other"},{"subitem_subject":"human induced pluripotent stem cell-derived cardiac myocytes","subitem_subject_scheme":"Other"},{"subitem_subject":"inotropic vasodilator","subitem_subject_scheme":"Other"},{"subitem_subject":"neonate","subitem_subject_scheme":"Other"},{"subitem_subject":"pediatric heart failure","subitem_subject_scheme":"Other"},{"subitem_subject":"TRV027","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-01"},"publish_date":"2022-12-01","publish_status":"0","recid":"2001244","relation_version_is_last":true,"title":["β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:41:53.174631+00:00"}