{"created":"2022-12-28T00:53:28.986584+00:00","id":2001261,"links":{},"metadata":{"_buckets":{"deposit":"0c9fac9a-8d81-41e1-858d-3ab140ce197a"},"_deposit":{"id":"2001261","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2001261"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:02001261","sets":["882:883"]},"author_link":[],"control_number":"2001261","item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"23","bibliographicPageStart":"6015","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Cancers"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Various risk factors and causative genes of osteosarcoma have been reported in the literature; however, its etiology remains largely unknown. Bone formation is a shared phenomenon in all types of osteosarcomas, and sclerostin is an extracellular soluble factor secreted by osteocytes that prevents bone formation by inhibiting the Wnt signaling pathway. We aimed to investigate the antitumor effect of sclerostin against osteosarcoma. Osteosarcoma model mice were prepared by transplantation into the dorsal region of C3H/He and BALB/c-nu/nu mice using osteosarcoma cell lines LM8 (murine) and 143B (human), respectively. Cell proliferations were evaluated by using alamarBlue and scratch assays. The migratory ability of the cells was evaluated using a migration assay. Sclerostin was injected intraperitoneally for 7 days to examine the suppression of tumor size and extension of survival. The administration of sclerostin to osteosarcoma cells significantly inhibited the growth and migratory ability of osteosarcoma cells. Kaplan–Meier curves and survival data demonstrated that sclerostin significantly inhibited tumor growth and improved survival. Sclerostin suppressed the proliferative capacity and migratory ability of osteosarcoma cells. Osteosarcoma model mice inhibited tumor growth and prolonged survival periods by the administration of sclerostin. The effect of existing anticancer drugs such as doxorubicin should be investigated for future clinical applications.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Cancers 13(23) : 6015(2021)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"吉田, 和薫","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.ZeyVPUym.html"},{"subitem_link_text":"岡本, 正則","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.uafabVym.html"},{"subitem_link_text":"鬼頭, 宗久","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.jmAFbVym.html"},{"subitem_link_text":"青木, 薫","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.WeDpbhym.html"},{"subitem_link_text":"吉村, 康夫","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.ONfaHhkh.html"},{"subitem_link_text":"田中, 厚誌","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.upkUPpym.html"},{"subitem_link_text":"羽二生, 久夫","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html"},{"subitem_link_text":"植村, 健","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.HmANWayV.html"},{"subitem_link_text":"滝沢, 崇","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.OhTebVym.html"},{"subitem_link_text":"鎌仲, 貴之","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.yFyVPUym.html"},{"subitem_link_text":"髙橋, 淳","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.jeAhuakh.html"},{"subitem_link_text":"加藤, 博之","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html"},{"subitem_link_text":"齋藤, 直人","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"34885123"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/34885123/","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.3390/cancers13236015"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/cancers13236015","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2072-6694","subitem_source_identifier_type":"EISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ideta, Hirokazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshida, Kazushige","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okamoto, Masanori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sasaki, Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kito, Munehisa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Aoki, Kaoru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshimura, Yasuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suzuki, Shuichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanaka, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takazawa, Akira","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Haniu, Hisao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Uemura, Takeshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takizawa, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sobajima, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kamanaka, Takayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takahashi, Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kato, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Saito, Naoto","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-28"}],"filename":"cancers13_06015.pdf","format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"cancers13_06015.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/2001261/files/cancers13_06015.pdf"},"version_id":"658e9888-ac7a-43c7-8c72-39aa0e7fdf80"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"osteosarcoma","subitem_subject_scheme":"Other"},{"subitem_subject":"sclerostin","subitem_subject_scheme":"Other"},{"subitem_subject":"Wnt pathway","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Antitumor Effect of Sclerostin against Osteosarcoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antitumor Effect of Sclerostin against Osteosarcoma","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["883"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-28"},"publish_date":"2022-12-28","publish_status":"0","recid":"2001261","relation_version_is_last":true,"title":["Antitumor Effect of Sclerostin against Osteosarcoma"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-20T06:34:33.942378+00:00"}