{"_buckets": {"deposit": "0527a55e-b682-44c0-8fe2-21465e3d1f47"}, "_deposit": {"id": "2001264", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2001264"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:02001264", "sets": []}, "author_link": [], "control_number": "2001264", "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-11-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "22", "bibliographicPageStart": "5525", "bibliographicVolumeNumber": "20", "bibliographic_titles": [{"bibliographic_title": "International journal of molecular sciences"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a cytokine involved in various biological phenomena including ontogeny, morphogenesis, carcinogenesis, and maintenance of stem cells. The Wnt signaling pathway can be classified into two main pathways: canonical and non-canonical. Of these, the canonical Wnt signaling pathway promotes osteogenesis. Sclerostin produced by osteocytes is an inhibitor of this pathway, thereby inhibiting osteogenesis. Recently, osteoporosis treatment using an anti-sclerostin therapy has been introduced. In this review, the basics of Wnt signaling, its role in bone metabolism and its involvement in skeletal disorders have been covered. 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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1422-0067", "subitem_source_identifier_type": "EISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1422-0067", "subitem_source_identifier_type": "EISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Maeda, Kazuhiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Yasuhiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Koide, Masanori", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Uehara, Shunsuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Okamoto, Masanori", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ishihara, Akihiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kayama, Tomohiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Saito, Mitsuhiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Marumo, Keishi", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-12-28"}], "download_preview_message": "", "file_order": 0, "filename": "IJMS20_5525.pdf", "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_0", "mimetype": "application/pdf", "size": 0, "url": {"label": "IJMS20_5525.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/2001264/files/IJMS20_5525.pdf"}, "version_id": "9d0bf578-2a61-4602-892e-0739b772565c"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "osteoclast", "subitem_subject_scheme": "Other"}, {"subitem_subject": "osteoblast", "subitem_subject_scheme": "Other"}, {"subitem_subject": "osteocyte", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Wnt", "subitem_subject_scheme": "Other"}, {"subitem_subject": "sclerostin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "osteoporosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "romosozumab", "subitem_subject_scheme": "Other"}, {"subitem_subject": "osteoarthritis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "rheumatoid arthritis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "skeletal-related events", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The Regulation of Bone Metabolism and Disorders by Wnt Signaling", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The Regulation of Bone Metabolism and Disorders by Wnt Signaling", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["883"], "permalink_uri": "http://hdl.handle.net/10091/0002001264", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-12-28"}, "publish_date": "2022-12-28", "publish_status": "0", "recid": "2001264", "relation": {}, "relation_version_is_last": true, "title": ["The Regulation of Bone Metabolism and Disorders by Wnt Signaling"], "weko_shared_id": -1}