{"created":"2023-01-18T07:36:18.150045+00:00","id":2001269,"links":{},"metadata":{"_buckets":{"deposit":"aeedc464-4359-43c0-ae9e-7a2445a4c53f"},"_deposit":{"id":"2001269","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2001269"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:02001269","sets":["461:462"]},"author_link":[],"control_number":"2001269","item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"e01637","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Heliyon"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hepatic iron deposition is seen in cases of chronic hepatitis and cirrhosis, and is a hallmark of a poorer prognosis. Iron deposition is also found in non-alcoholic steatohepatitis (NASH) patients. We have now developed a mouse model of NASH with hepatic iron deposition by combining a methione- and choline-deficient (MCD) diet with an iron-overload diet. Using this model, we evaluated the effects of human placenta extract (HPE), which has been shown to ameliorate the pathology of NASH. Four-week-old male C57BL/6 mice were fed the MCD diet with 2% iron for 12 weeks. In liver sections, iron deposition was first detected around the portal vein after 1 week. From there it spread throughout the parenchyma. Biliary iron concentrations were continuously elevated throughout the entire 12-week diet. As a compensatory response, the diet caused elevation of serum hepcidin, which accelerates excretion of iron from the body. Accumulation of F4/80-positive macrophages was detected within the sinusoids from the first week onward, and real-time PCR analysis revealed elevated hepatic expression of genes related inflammation and oxidative stress. In the model mice, HPE treatment led to a marked reduction of hepatic iron deposition with a corresponding increase in biliary iron excretion. Macrophage accumulation was much reduced by HPE treatment, as was the serum oxidation-reduction potential, an index of oxidative stress. These data indicate that by suppressing inflammation, oxidative stress and iron deposition, and enhancing iron excretion, HPE effectively ameliorates iron overload-induced liver injury. HPE administration may thus be an effective strategy for treating NASH.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Heliyon 5(5) : e01637-(2019)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"神吉, 昭子","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.OpLVuNkh.html"},{"subitem_link_text":"桜井, 敬之","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.jaLUuNkh.html"},{"subitem_link_text":"新藤, 隆行","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.OCLpOayV.html"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"31193082"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/31193082/","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1016/j.heliyon.2019.e01637"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.heliyon.2019.e01637","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2405-8440","subitem_source_identifier_type":"EISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamauchi, Akihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kamiyoshi, Akiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sakurai, Takayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miyazaki, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirano, Eiichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Lim, Hong Seok","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kaku, Taiichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shindo, Takayuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-01-19"}],"filename":"18H02602_2.pdf","format":"application/pdf","licensefree":"© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"18H02602_2.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/2001269/files/18H02602_2.pdf"},"version_id":"4cd55197-394e-42dc-8220-ef7d420b251f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Molecular biology","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-01-19"},"publish_date":"2023-01-19","publish_status":"0","recid":"2001269","relation_version_is_last":true,"title":["Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-18T08:14:50.149773+00:00"}