{"created":"2023-01-18T07:36:18.154789+00:00","id":2001270,"links":{},"metadata":{"_buckets":{"deposit":"615c35aa-ea35-446f-85e1-732ed7ac74df"},"_deposit":{"id":"2001270","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2001270"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:02001270","sets":["461:462"]},"author_link":[],"control_number":"2001270","item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-10-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"e02655","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Heliyon"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cachexia is an intractable metabolic disorder that causes extreme weight loss. It is a symptom of many chronic diseases, including cancer, liver failure, congestive heart failure and chronic kidney disease, and there is as yet no effective treatment. While the mechanisms underlying cachexia are complex, it is often accompanied by elevated angiotensin II (Ang II). Human placental extract (HPE) is a source of numerous biologically active molecules and has been used clinically to treat chronic hepatitis, liver cirrhosis and other chronic diseases. Here, we investigated the effects of HPE in an Ang II-induced cachexia model in mice. HPE treatment preserved both fat mass and lean body mass and suppressed weight loss in the cachexia model, though food intake was unaffected. Ang II infusion also caused cardiac hypertrophy and fibrosis. HPE suppressed these effects as well as Ang II-induced cardiac expression of genes related to heart failure and cardiac remodeling. HPE also reversed Ang II-induced downregulation of mitochondria-related molecules and suppressed cardiac inflammation and oxidative stress. HPE administration may thus be an effective approach to the treatment of cachexia, cardiac hypertrophy and fibrosis.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Heliyon 5(10) : e02655-(2019)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"神吉, 昭子","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.OpLVuNkh.html"},{"subitem_link_text":"桜井, 敬之","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.jaLUuNkh.html"},{"subitem_link_text":"新藤, 隆行","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.OCLpOayV.html"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"31667435"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/31667435/","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1016/j.heliyon.2019.e02655"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.heliyon.2019.e02655","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2405-8440","subitem_source_identifier_type":"EISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamauchi, Akihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kamiyoshi, Akiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sakurai, Takayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miyazaki, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirano, Eiichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Lim, Hong Seok","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kaku, Taiichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shindo, Takayuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-01-19"}],"filename":"18H02602_1.pdf","format":"application/pdf","licensefree":"© 2019 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"18H02602_1.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/2001270/files/18H02602_1.pdf"},"version_id":"0a2e7b80-b905-4dd1-8b42-3229bc343f27"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Biochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"Cardiac hypertrophy","subitem_subject_scheme":"Other"},{"subitem_subject":"Human placenta extract","subitem_subject_scheme":"Other"},{"subitem_subject":"Cardiac fibrosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Angiotensin II","subitem_subject_scheme":"Other"},{"subitem_subject":"Cachexia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Placental extract suppresses cardiac hypertrophy and fibrosis in an angiotensin II-induced cachexia model in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Placental extract suppresses cardiac hypertrophy and fibrosis in an angiotensin II-induced cachexia model in mice","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-01-19"},"publish_date":"2023-01-19","publish_status":"0","recid":"2001270","relation_version_is_last":true,"title":["Placental extract suppresses cardiac hypertrophy and fibrosis in an angiotensin II-induced cachexia model in mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-18T08:17:44.175079+00:00"}