{"created":"2023-01-26T06:03:00.910555+00:00","id":2001279,"links":{},"metadata":{"_buckets":{"deposit":"30120c04-d76e-4bd4-8185-7bee5679ac6d"},"_deposit":{"id":"2001279","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2001279"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:02001279","sets":["461:462"]},"author_link":[],"control_number":"2001279","item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-07-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"3181759","bibliographicVolumeNumber":"2018","bibliographic_titles":[{"bibliographic_title":"Oxidative medicine and cellular longevity"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Oxidative damage in endothelial cells is proposed to play an important role in endothelial dysfunction and atherogenesis. We previously reported that the reduced form of coenzyme Q10 (CoQ10H2) effectively inhibits oxidative stress and decelerates senescence in senescence-accelerated mice. Here, we treated human umbilical vein endothelial cells (HUVECs) with H2O2 and investigated the protective effect of CoQ10H2 against senescence, oxidative damage, and reduction in cellular functions. We found that CoQ10H2 markedly reduced the number of senescence-associated β-galactosidase-positive cells and suppressed the expression of senescence-associated secretory phenotype-associated genes in H2O2-treated HUVECs. Furthermore, CoQ10H2 suppressed the generation of intracellular reactive oxygen species (ROS) but promoted NO production that was accompanied by increased eNOS expression. CoQ10H2 prevented apoptosis and reductions in mitochondrial function and reduced migration and tube formation activity of H2O2-treated cells. The present study indicated that CoQ10H2 protects endothelial cells against senescence by promoting mitochondrial function and thus could delay vascular aging.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Oxidative medicine and cellular longevity 2018 : 3181759, (2018)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"宮原, 大貴","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.OhLmPNym.html"},{"subitem_link_text":"代, 健","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.ZacNuhkh.html"},{"subitem_link_text":"森, 政之","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html"},{"subitem_link_text":"樋口, 京一","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Hindawi Ltd."}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"30116476"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/30116476/","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1155/2018/3181759"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1155/2018/3181759","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 Jia Huo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1942-0994","subitem_source_identifier_type":"EISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Huo, Jia","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Xu, Zhe","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hosoe, Kazunori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kubo, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miyahara, Hiroki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Dai, Jian","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mori, Masayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sawashita, Jinko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Higuchi, Keiichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-01-26"}],"filename":"17K19900_3.pdf","format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"17K19900_3.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/2001279/files/17K19900_3.pdf"},"version_id":"5ffd4569-a77d-4b06-aba2-43f95b694109"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-01-26"},"publish_date":"2023-01-26","publish_status":"0","recid":"2001279","relation_version_is_last":true,"title":["Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-22T00:28:54.711066+00:00"}